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طبق اظهارات مقام های ارشد نیروی هوایی ارتش آمریکا، این نیرو قصد دارد با صرف بودجه ای 2/3 میلیارد دلاری ظرفیت فعلی ناوگان بمب افکن های خود را تا سال 2009 ارتقاء بخشد. هرچند به تازگی صحبت های درباره ایجاد یک ظرفیت جدید هواپیماهای ضربتی بلند برد بوده است، ولی آنچه مسلم است ناوگان فعلی متشکل از هواپیماهای B-1B Lancer، B-2A Spirit و B-52H استراتژیک قاره پیما (8 موتوره ) است که تا سال 2040 توان ضر...
Vascular disrupting agents (VDAs) are an emerging class of therapeutics targeting the existing vascular network of solid tumors. However, their clinical progression has been hampered because of limited single-agent efficacy, primarily caused by the persistence of surviving cells at the well perfused "viable rim" of tumors, which allows rapid tumor regrowth to occur. In addition, off-target adve...
The metabolic stress-sensing enzyme AMP-activated protein kinase (AMPK) is responsible for regulating metabolism in response to energy supply and demand. Drugs that activate AMPK may be useful in the treatment of metabolic diseases including type 2 diabetes. We have determined the crystal structure of AMPK in complex with its activator 5-(5-hydroxyl-isoxazol-3-yl)-furan-2-phosphonic acid (C2), ...
It is conjectured that a hyperbolic knot complement does not contain a closed embedded totally geodesic surface. In this paper, we show that there are no such surfaces in the complements of hyperbolic 3-bridge knots and double torus knots. Some topological criteria for a closed essential surface failing to be totally geodesic are given. Roughly speaking, sufficiently ‘complicated’ surfaces can ...
Food intake triggers convulsions in fasted BALB/c mice and Wistar albino rats treated with antimuscarinic drugs, scopolamine or atropine. Inbred strain studies have yielded considerable information regarding genetic influences on seizure susceptibility and factors contribute to epileptogenesis in rodents. This study, therefore, investigated sensitivity to antimuscarinic-induced seizures in C57B...
In this paper, we analyze complemented group Cellular Automata (CA) derived from Linear Hybrid Group CA with rules 60, 102 and 204. We analyze some properties of the CA. And we give rule vectors which determine the state transition of the CA dividing the entire state space into smaller spaces of equal lengths, and find conditions for the complement vectors corresponding to the rule vectors. And...
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