Phosphorylation of phospholipids was studied in Langendorff perfused guinea pig hearts subjected to beta-adrenergic stimulation. Hearts were perfused with Krebs-Henseleit buffer containing [32P]Pi and freeze-clamped in a control condition or at the peak of the inotropic response to isoprenaline. 32P incorporation into total phospholipids, individual phospholipids and polyphosphoinositides was a...

OBJECTIVE To assess the diagnostic value and safety of sublingual glyceryl trinitrate tilt testing compared with isoprenaline infusion in patients with unexplained syncope. DESIGN Glyceryl trinitrate and isoprenaline tilt tests were performed in two successive days on a random basis in cases and controls. SETTING Outpatient cases with syncope referred to Shahid Rajaii Heart Hospital. SUBJ...

Objective—To assess the diagnostic value and safety of sublingual glyceryl trinitrate tilt testing compared with isoprenaline infusion in patients with unexplained syncope. Design—Glyceryl trinitrate and isoprenaline tilt tests were performed in two successive days on a random basis in cases and controls. Setting—Outpatient cases with syncope referred to Shahid Rajaii Heart Hospital. Subjects—6...

We examined the contribution of large-conductance, Ca(2+)-sensitive K+ (MaxiK) channel to beta2-adrenoceptor-activated relaxation to isoprenaline in guinea-pig tracheal smooth muscle focusing on the role for cAMP in the coupling between beta2-adrenoceptor and MaxiK channel. Isoprenaline-elicited relaxation was confirmed to be mediated through beta2-type of adrenoceptor since the response was an...

Objective(s): Recently, we showed that some new synthetic compounds structurally related to cilostamide (4-(1,2-dihydro-2-oxoquinolin-6-hydroxy)- N-cyclohexyl-N-methylbutanamide), a selective phosphodiesterase 3 (PDE3) inhibitor, produce inotropic effect comparable to that of IBMX (3-isobutyl-1-methylxanthine), a non-selective PDE inhibitor, but with differential chronotropic effect. In this in...

The beta-adrenoceptor agonist, isoprenaline, elicits vasodilation and tachycardia in anesthetized rats via activation of propranolol-sensitive beta1- and beta2-adrenoceptors and also by propranolol-insensitive beta1- and beta3-adrenoceptors. The aim of this study was to determine whether the relative contribution of propranolol-sensitive and -insensitive beta-adrenoceptors to the changes in hea...

objective: the study was conducted to evaluate cardioprotective effect of silk cocoon (abresham) bombyx mori (b. mori) on isoprenaline-induced myocardial infarction. this study deals with the cocoons, which is called abresham in the unani system of medicine. it is one of the 64 drugs which avicenna has mentioned in avicenna’s tract on cardiac drugs and used in the treatment of cardiovascular di...

Results 98 (69 male and 29 female) such patients were transported, and 13 were on Temporary Pacemakers. 97 were inter-hospital transfers. 43 (44.3%) patients were transported with Isoprenaline (average dose 2.7 mcg/min, range 1 to 8.2mcg/min); 8 with Dopamine, and 7 on external cardiac pacing. 30 patients were on Isoprenaline and 8 on Dopamine in previous hospitals, and the same drug with simil...

Nine IDDM-patients with hypoglycaemia unawareness, seven IDDM-patients with hypoglycemia awareness and a control group of nine healthy persons were included in this study. The patients were recruited from the medical out-patients' department of the University Hospital of Tromsø. The pathophysiological changes which cause hypoglycaemia unawareness are today not clear. Reduced peripheral tissue s...

BACKGROUND AND AIMS The subtype and species related heterogeneity of beta adrenoceptors prompted a functional reappraisal of these molecular targets of motility inhibition in the human colon. METHODS Relaxation of muscle strips was measured in vitro. RESULTS The following agonists had decreasing relaxing potency (effective concentration range 10(-8)-10(-4) mol/l): (-)isoprenaline (non-selec...