AIM To investigate the changes and contributions of superior mesenteric venous perfusion (SMVP) and splenic venous perfusion (SpVP) to portal venous CT perfusion in canine model of hepatic diffuse disease. MATERIALS AND METHODS By selective catheterization in superior mesenteric and splenic arteries respectively after CT perfusion scanning, SMVP and SpVP became available. Sixteen dogs were ad...

Abstract Aims Up to 85% of patients with liver metastases have inoperable hepatic tumour burden. Isolated perfusion involves vascular isolation the in situ and regional delivery chemotherapy, avoiding dose-limiting extra-hepatic toxicity. In this series, we develop a surgical protocol demonstrate feasibility isolated normothermic (INLP) investigate short-term safety delivering high-dose chemoth...

Colorectal cancer is the third leading cause of cancer-related mortality in the world--the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP). Searching for the most clinically relevant approaches for treating colorectal metastatic disease by isolated hepatic perfusion (IHP), we developed the application of oxaliplatin co...

The hepatic uptake of high density lipoprotein cholesteryl ester was determine in a nonrecycling isolated rat liver perfusion. High density lipoprotein rich in the E apoprotein (apoE) showed about 10 times more uptake of the ester on a single pass than the bulk of the high density lipoproteins rich in the A-I protein. The apoportein recoveries in the liver paralleled the ester for both lipoprot...

BACKGROUND The aim of this study was to identify prognostic factors for local and systemic failure after isolated hepatic perfusion (IHP) with 200 mg melphalan in patients with colorectal liver metastases. PATIENTS AND METHODS Hundred and fifty-four patients were selected for IHP and underwent laparotomy. Patients were monitored for response, toxicity and survival. Univariate and multivariate...

1. A procedure is described for surgically isolating and artificially perfusing the liver of the young bovine. Heparinized autogenous blood from the hepatectomized animal diluted with Krebs-Ringer-bicarbonate solution is employed as the perfusate. 2. This preparation has been satisfactorily reproducible in this laboratory in more than 90 separate sequential perfusions. Absence of a sensitive he...

Perfusion computed tomography (CT) has a great potential for determining hepatic and portal blood flow; it offers the advantages of quantitative determination of lesion hemodynamics, distinguishing malignant and benign processes, as well as providing morphological data. Many studies have reported the use of this method in the assessment of hepatic tumors, hepatic fibrosis associated with chroni...

BACKGROUND Isolated hepatic perfusion (IHP) involves complete vascular isolation of the liver to allow treatment with doses that would be toxic if delivered systemically. A phase II study of IHP in patients with colorectal metastases confined to the liver was performed. METHODS Seventy-three patients with irresectable colorectal metastases underwent IHP with high-dose melphalan (200 mg) for 1...

The effect of human C-I, C-11, and C-111-2 apolipoproteins on the metabolism of triglyceride in triglyceride emulsions was studied in the in vitro perfused rat liver and the nonreplicating hepatocyte monolayer culture. All three human apolipoproteins delayed hepatic uptake of the triglyceride emulsion, both when the emulsion was supplemented with human apolipoprotein E and without this apolipop...