BACKGROUND Neutrophils are the predominant phagocytes in the early stages of myocardial ischemia-reperfusion response and are also implicated in the development of tissue damage. This study examined the role of recruited macrophages in the evolution of this tissue injury. METHODS Farm pigs were subjected to 30 minutes of myocardial ischemia followed by 30 minutes of reperfusion. Biopsy sample...

Aseptic osteonecrosis is a frequent pathology. It corresponds to epiphyseal bone necrosis, secondary ischemic and/or cytotoxic mechanisms. not specific disease, but rather the final outcome of various pathological situations in which there disturbance intraosseous circulation femoral head. This explains usual names avascular necrosis or aseptic necrosis. may be unilateral, bilateral multifocal....

Previously, we demonstrated that there were effects of elevated plasma osmolality on both early cell swelling and eventual cell necrosis in ischemic cardiac muscle. The present study quantifies the extent of cell volume derangement, determines whether or not there is a quantitative relationship between cell swelling and eventual necrosis, and defines the time limits of ischemia within which pre...

Tumor necrosis factor alpha (TNF-alpha) is a protein of a cellular origin belonging to a group of proinflammatory cytokines. A rapid overproduction of TNF-alpha in a cerebral post-ischemic inflammatory response leads to the stimulation of adhesive molecules expression with subsequent accumulation of leukocytes in the ischemic focus, which is preceded by their adhesion and migration. The TNF-alp...

BACKGROUND AND PURPOSE Transient distal platelet accumulation after common carotid artery thrombosis (CCAT) leads to hemodynamic, metabolic, and molecular events that may influence the response of the postthrombotic brain to secondary insults. We investigated how a thromboembolic insult would affect histopathological outcome when combined with an ischemic insult induced 24 hours later. METHOD...