conclusions our study demonstrates that preconditioning of kidney with chronic ptu administration protects renal tissue against iri and this phenomenon was mediated through no system. the results suggest a potential indication for using ptu to protect the kidney before transplantations and to reduce the risk of tissue rejection afterwards. background renal ischemia/reperfusion injury (iri) is a...

objectives:vagal pathways in gastrointestinal tract are the most important pathways that regulate ischemia/reperfusion (i/r).  gastrointestinal tract is one of the important sources of melatonin production. the aim of this study was to investigate probable protective effect of the interaction between vagus nerve and melatonin after i/r. materials and methods:this study was performed in male rat...

myocardial infarction is a common presentation of coronary artery disease and the leading cause of death worldwide. the present study was investigated potential resistance to ischemia-reperfusion (i/r) injuries following administration of methanolic (meoh) extract of scrophularia frigida (s. frigida) in isolated rat heart. male wistar rat hearts (n= 8-10) were isolated and allowed to equilibrat...

conclusions treatment with epo and mel had a beneficial effect on renal ir injury. the results may also indicate that mel protects against morphological damage better than epo in renal ir injury. results ischemia-reperfusion significantly decreased the observed hb and hct values. the histopathological findings in the ir group confirmed that there was an increase in the hyaline cast and thickeni...

aim: oxidative stress plays a crucial role in the pathophysiology of ischemic stroke. since water-solublefullerene derivatives act as the potent scavenger of oxygen free radicals in biological systems, we aimedto investigate the possible protective effects of fullerol nanoparticles on brain infarction and edema intransient model of focal cerebral ischemia in rat.materials & methods: experiment ...

introduction: stroke is one of the most important reasons of death. hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. the ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. the a1 adenosine receptoras an endogenous l...

conclusions the analysis of the pro-apoptotic gene to anti-apoptotic gene expression ratio (bad /bcl-xl) confirmed that expression of the pro-apoptotic gene significantly decreased (p value ˂ 0.001) under the ischemia/reperfusion condition. in contrast, the expression of the anti-apoptotic gene increased after administration of fk-506 (p value ˂ 0.001). results the quantitative results of real-...

A B S T R A C T Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with...

objective(s): the alteration of glucose transporters is closely related with the pathogenesis of brain edema. we compared neuronal damage/death in the hippocampus between adult and young gerbils following transient cerebral ischemia/reperfusion and changes of glucose transporter-1(glut-1)-immunoreactive microvessels in their ischemic hippocampal ca1 region. materials and methods: transient cere...

ischemia has an important role in spread of pathologic injuries in the neuropathies. it is widely accepted that most damages such as reperfusion injuries, are related to the activity of free radicals. apoptotic signaling was exacerbated by free radicals. the aim of this study was to evaluate the neuroprotective effect of human chorionic gonadotropin (hcg) and vitamin e (trolox) in the hippocamp...