OBJECTIVES To assess the relationship between haematocrit and risk of major ischaemic heart disease events. DESIGN Prospective study of a cohort of men followed up for 9.5 years. SETTING General practices in 24 towns in England, Wales, and Scotland (British Regional Heart Study). SUBJECTS Altogether 7735 men aged 40-59 years at screening, who were selected at random from one general pract...

There can be no truly objective frequency estimate of the susceptibility of the population to ischaemic heart disease: everybody has some degree of susceptibility. The disease kills 1 in 4 of the population, and 1 man in 10 dies of ischaemic heart disease before 65 years of age. The major burden is mortality, though there is often some degree of impairment among survivors of acute attacks. It i...

The mortality from ischaemic heart disease was studied in a prospective cohort of 1725 shipyard workers exposed to asbestos. The analyses were stratified for age and smoking habits and restricted to men. In agreement with other findings, men with impaired lung function had a significantly higher risk (relative risk (RR) = 3.5) of dying from ischaemic heart disease than men with normal lung func...

OBJECTIVE To determine whether Helicobacter pylori infection is associated with the development of ischaemic heart disease and whether such infection can explain the social class inequality in ischaemic heart disease. DESIGN Cardiovascular risk factor levels, prevalence of ischaemic heart disease (Rose questionnaire angina, and/or a history of myocardial infarction), and serum antibodies to H...

OBJECTIVES To investigate the effect of Chlamydia pneumoniae infection on future development of ischaemic heart disease and mortality. DESIGN Prospective longitudinal study. SETTING Caerphilly, South Wales. SUBJECTS Plasma specimens were collected during 1979-83 from 1773 men aged 45-59 years. These were tested for IgG and IgA antibodies to C pneumoniae (TW183) by microimmunofluorescence....

OBJECTIVE To study the prevalence of ischaemic heart disease in Turkish and Surinam-Asian migrants with type 2 diabetes mellitus in the Netherlands as compared with Europeans. METHODS In a consecutive case-control study, 59 Turkish and 62 Surinam-Asian patients were compared with 185 Europeans referred to a diabetes clinic for treatment of type 2 diabetes in the period 1992 to 1998. Main outc...

OBJECTIVE To describe the long-term outcome of different forms of symptomatic and asymptomatic ischaemic heart disease in middle-aged men. METHODS 7735 men aged 40-59, randomly selected from 24 general practices in Britain were classified into one of seven ischaemic heart disease groups according to a questionnaire and electrocardiogram (ECG): I=diagnosed myocardial infarction; II=unrecognize...

The importance of three risk factors--serum total cholesterol, systolic blood pressure, and cigarette smoking--on the risk of new major ischaemic heart disease events in men who already have evidence of ischaemic heart disease was assessed. Data from the initial examination in a large prospective study of cardiovascular disease in middle aged men (the British Regional Heart Study) were used to ...