BACKGROUND The prevalence of carbapenem-resistant Acinetobacter baumannii in hospitals has been increasing worldwide. This study aims to investigate the carbapenemase genes and the clonal relatedness among A. baumannii clinical isolates in a Chinese hospital. METHODS Carbapenemase genes and the upstream locations of insertion sequences were detected by polymerase chain reaction (PCR), and the...

Acinetobacter baumannii pigmented strains are not common in clinical settings. Here, we report an outbreak caused by indigo-pigmented A. baumannii strains isolated in an acute care hospital in Argentina from March to September 2012. Pan-PCR assays exposed a unique pattern belonging to the recently described regional CC113(B)/CC79(P) clonal complex that confirms the relevant relationships among ...

Carbapenem resistance in Acinetobacter baumannii is typically mediated by the acquisition of class D -lactamases belonging to gene clusters of blaOXA-23-like, blaOXA-40-like, and blaOXA-58like (1). In the Enterobacteriaceae, carbapenem-hydrolyzing class D -lactamases are encoded by a dissimilar set of genes, the blaOXA-48-like genes (2). The presence of blaOXA-23 in Enterobacteriaceae is except...

Sir, Worldwide, resistance to carbapenems, imipenem and meropenem is widespread among Acinetobacter causing infections and most resistant isolates are also resistant to many other antibiotic classes. Several class D b-lactamases can hydrolyse carbapenems, conferring resistance. The blaOXA-23 gene was the first to be found and was originally identified in a conjugative plasmid from a clinical Ac...

We investigated the resistance determinant of 13 clinical isolates of carbapenem-resistant Acinetobacter baumannii collected from a regional hospital in the north of Thailand. All isolates were multidrug resistant and produced the OXA-23 carbapenemase. The bla(OXA-23) gene was found adjacent to ISAba1. Furthermore, two isolates carried the metallo beta-lactamase gene, bla(IMP). The bla(OXA-23) ...

Multidrug resistance in the nosocomial pathogen Acinetobacter baumannii limits therapeutic options and impacts on clinical care. Resistance against carbapenems, a group of last-resort antimicrobials for treating multidrug-resistant (MDR) A. baumannii infections, is associated with the expression (and over-expression) of carbapenemases encoded by the blaOXA genes. The aim of this study was to de...

Carbapenem-resistant Acinetobacter baumannii (CR-AB) causes serious nosocomial infections, especially in ICU wards of hospitals, worldwide. Expression of bla OXA genes is the chief mechanism of conferring carbapenem resistance among CR-AB. Although some bla OXA genes have been studied among CR-AB isolates from Iran, their bla OXA-23-like genes have not been investigated. We used a multiplex-PCR...