Obesity is frequently associated with systemic insulin resistance, glucose intolerance, and hyperlipidemia. Impaired insulin action in muscle and paradoxical diet/insulin-dependent overproduction of hepatic lipids are important components of obesity, but their pathogenesis and inter-relationships between muscle and liver are uncertain. We studied two murine obesity models, moderate high-fat-fee...

Exposure to high glucose may cause glucotoxicity, leading to pancreatic β cell dysfunction including cell apoptosis, impaired glucose‑stimulated insulin secretion (GSIS) and intracellular lipid accumulation. Sterol regulatory element binding protein-1c (SREBP-1c), a key nuclear transcription factor that regulates lipid metabolism, has been proven to play a role in insulin secretion. Insulin ind...

Road, railway and track networks are important features of satellite imagery. Automated detection of tracks in mountainous terrain using satellite imagery is a difficult task. The track and the shadow signature of the mountainous terrain are almost same. The presence of ridges and snow also creates a lot of ambiguity. Moreover due to poor sunlight condition in the mountainous terrain the images...

Extraction of vegetation is an important step for agricultural, forest and greenery mapping. The proposed method examines the complex process of land cover vegetation pattern classification using an IRS-1C LISS III image. Pre-processing was done by employing partial differential equation (PDE). Normalized differential vegetation index (NDVI) was applied to separate vegetation features from the ...

This paper examines data from different sensors regarding their potential for an automatic change detection approach. After a brief discussion of the used approach, results are shown on examples of data from several sensors: scanned analogue aerial photos, an airborne digital line scanner (DPA camera system), the Indian satellite IRS-1C, the MOMS2P camera and from a laser scanning system as an ...

In continuation of IRS-1C/1D mission, Resourcesat mission was planned for integrated land and water resource management. Resourcesat was launched on 17 October 2003. This satellite carries three multi-spectral cameras with variable swath and different spatial resolution. Data quality evaluation (DQE) system characterizes payload and platform performance and its impact on radiometric and geometr...

The flavonoid naringenin improves hyperlipidemia and hyperglycemia in streptozotocin-treated rats. In HepG2 human hepatoma cells, naringenin inhibits apolipoprotein B (apoB) secretion primarily by inhibiting microsomal triglyceride transfer protein and enhances LDL receptor (LDLr)-mediated apoB-containing lipoprotein uptake. Phosphatidylinositol 3-kinase (PI3K) activation by insulin increases s...

Thiazolidinediones (TZDs) improve glycemic control and insulin sensitivity in patients with type 2 diabetes. To determine whether the TZD-induced improvement in glycemic control is associated with enhanced insulin receptor signaling in skeletal muscle, 20 type 2 diabetic patients received a 75-g oral glucose tolerance test (OGTT) and euglycemic insulin (80 mU x m(-2) x min(-1)) clamp with [3-(3...