The key factor in the production of pulp and periapical inflammation is represented by the presence of bacteria in the root canal system and the outcoming toxins. Bacterial biofilm is identifiable in the various areas of the endodontic space, but due to the complexity of the internal anatomy of the root canal, bacteria removing is yet difficult to obtain, a particularly important step for treat...

INTRODUCTION One of the main goals of endodontic treatment is to decrease the harboring bacteria within the root canal system and dentinal tubules. This experimental study attempted to investigate the antibacterial efficacy of three root canal irrigants in the presence and absence of smear layer (SL). METHODS AND MATERIALS A total of 210 sound extracted human single-rooted teeth were prepared...

Our primary objective was to measure root canal penetrations of aqueous antibacterial nano-chitosan (Nano-CS), for the first time. The second objective was to compare and contrast such penetrations to those of chitosan (CS) itself, as well as sodium hypochlorite (NaOCl), chlorhexidine (CHX) and ethylenediamintetraacetic acid (EDTA), at the routinely used concentrations. Molar roots were split l...

INTRODUCTION This systematic review aimed to compare the effectiveness of sodium hypochlorite and chlorhexidine for root canal disinfection during root canal therapy. METHODS A literature search for clinical trials was made on the PubMed (MEDLINE), Web of Knowledge, SCOPUS, and Science Direct databases and in the reference lists of the identified articles up to January 2015. Quality assessmen...

BACKGROUND There are various microorganisms related to intra and extra-radicular infections and many of these are involved in persistent infections. Bacterial elimination from the root canal is achieved by means of the mechanical action of instruments and irrigation as well as the antibacterial effects of the irrigating solutions. Enterococcus faecalis can frequently be isolated from root canal...

BACKGROUND Cytotoxicity of root canal irrigants is important due to their close contact with host tissues. The aim of this study was to assess the cytotoxic effect of NaOCl 3%, Chx 2%, and MTAD on rat periodontal ligament fibroblasts, at 0.1 and 100 µl/mL, using WST-1 colorimetric method. MATERIAL AND METHODS Rat ligamental fibroblasts were exposed to the irrigants and their viability was ass...

Objectives: The aim of this study was to evaluate whether the gelatinase production ability of Enterococcus faecalis provides any advantage on adhesion of this bacterium to dentin treated with various irrigants and their combinations. Materials and methods: Standardized dentin discs were randomly divided into five groups (n = 20): group 1: 2.5% sodium hypochlorite (NaOCl), group 2: 2% chlorhexi...

Effective irrigant delivery and agitation are prerequisites to promote root canal disinfection and debris removal and improve successful endodontic treatment. This paper presents an overview of the currently available technologies to improve the cleaning of the endodontic space and their debridement efficacy. A PubMed electronic search was conducted with appropriate key words to identify the re...