The stability of enzyme-conjugated magnetic iron oxide nanoparticles in plasma is of great importance for in vivo delivery of the conjugated enzyme. In this study, β-glucosidase was conjugated on aminated magnetic iron oxide nanoparticles using the glutaraldehyde method (β-Glu-MNP), and further PEGylated via N-hydroxysuccinimide chemistry. The PEG-modified, β-glucosidase-immobilized magnetic ir...

background: ultrasmallsuperparamagnetic iron oxide (uspio) nanoparticles are used as blood pool contrast agent for magnetic resonance angiography and perfusion imaging. our aim in this study was to investigate the effect of the two coating types of iron oxide nanoparticles on the relationship between nanoparticles concentration and signal intensity (si) in t1-weighted mr images.   methods : dif...

Recently, magnetic iron oxide particles have been emerged as significant nanomaterials due to its extensive range of application in various fields. In this regard, synthesis of iron oxide nanoparticles with desirable properties and high potential applications are greatly demanded. Therefore, investigation on different iron oxide phases and their magnetic properties along with various commonly u...

in this work, we report synthesis of surface modified superparamagnetic iron oxide nanoparticles (spion) by co-precipitation method using feso4.7h2o and fe2(so4)3.5h2o as precursors and trisodium citrate dihydrate as surfactant. surface modification of the as prepared samples was performed in pot by sol-gel precipitation method using tetraethoxysilane (teos). the structure, morphology, and magn...

BACKGROUND AND METHODS Magnetic iron oxide nanoparticles were prepared using a sonochemical method under atmospheric conditions at a Fe²⁺ to Fe³⁺ molar ratio of 1:2. The iron oxide nanoparticles were subsequently coated with chitosan and gallic acid to produce a core-shell structure. RESULTS X-ray diffraction demonstrated that the magnetic nanoparticles were pure Fe₃O₄ with a cubic inverse sp...

Enshrined in this review are the biogenic fabrication and applications of coated and uncoated iron and iron oxide nanoparticles. Depending on their magnetic properties, they have been used in the treatment of cancer, drug delivery system, MRI, and catalysis and removal of pesticides from potable water. The polymer-coated iron and iron oxide nanoparticles are made biocompatible, and their slow r...

Using magnetic nanoparticles to absorb alternating magnetic field energy as a method of generating localized hyperthermia has been shown to be a potential cancer treatment. This report demonstrates a system that uses tumor homing cells to actively carry iron/iron oxide nanoparticles into tumor tissue for alternating magnetic field treatment. Paramagnetic iron/ iron oxide nanoparticles were synt...

Purpose: The presence of tumor-associatedmacrophages (TAM) in breast cancer correlates strongly with poor outcome. The purpose of this study was to develop a clinically applicable, noninvasive diagnostic assay for selective targeting and visualization of TAMs in breast cancer, based on magnetic resonanceI and clinically applicable iron oxide nanoparticles. Experimental Design: F4/80-negativemam...

Objective(s): This study was designed to evaluate the effect of Fe3O4 nanoparticles at presence of a constant magnetic field on rat liver and some stress oxidative parameters.Materials and Methods: Fe3O4 nanoparticles were synthesized by co-precipitation method using iron chloride (III) and iron sulphate (II). The nanoparticles properties were studied by XRD and TEM. Fourty male wistar rats wer...