نتایج جستجو برای: irgm

تعداد نتایج: 117  

2014
Alan Raybould Andrea Burns Mick Hamer

Laboratory testing for possible adverse effects of insecticidal proteins on non-target organisms (NTOs) is an important part of many ecological risk assessments for regulatory decision-making about the cultivation of insect-resistant genetically modified (IRGM) crops. To increase confidence in the risk assessments, regulatory guidelines for effects testing specify that representative surrogate ...

Journal: :Blood 2010
Yume Nguyen Abed Al-Lehibi Elizabeth Gorbe Ellen Li Michael Haagenson Tao Wang Stephen Spellman Stephanie J Lee Nicholas O Davidson

Previous European studies suggest NOD2/CARD15 and interleukin-23 receptor (IL-23R) donor or recipient variants are associated with adverse clinical outcomes in allogeneic hematopoietic stem cell transplantation. We reexamined these findings as well as the role of another inflammatory bowel disease (IBD) susceptibility gene (immunity-related GTPase family, M [IRGM]) on transplantation outcomes i...

2017
Miles Parkes Jeffrey C Barrett Natalie Prescott Mark Tremelling Carl A Anderson Sheila A Fisher Roland G Roberts Elaine R Nimmo Fraser R Cummings Dianne Soars Hazel Drummond Charlie W Lees Saud A Khawaja Richard Bagnall Denis A Burke Catherine E Todhunter Tariq Ahmad Clive M Onnie Wendy McArdle David Strachan Graeme Bethel Claire Bryan Panos Deloukas Alastair Forbes Jeremy Sanderson Derek P Jewell Jack Satsangi John C Mansfield Christopher G Mathew

A genome-wide association scan in Crohn disease by the Wellcome Trust Case Control Consortium1 detected strong association at 6 novel loci. We tested 37 SNPs from these and other loci for association in an independent case control sample. Replication was obtained for the IRGM gene on chromosome 5q33.1 which induces autophagy (replication P = 6.6 × 10−4, combined P = 2.1 × 10−10), and for 9 othe...

Journal: :Journal of Crohn's & colitis 2016
Marco Genua Christoph Becker Stefania Vetrano

Crohn's disease [CD] and ulcerative colitis [UC] are the two major forms of inflammatory bowel disease [IBD]. First-line therapies are based on neutralisation of the immune system by corticosteroids, or on blockage of pro-inflammatory cytokines such as tumour necrosis factor-α [TNF-α]. 1 It is now becoming clear that these treatments required a personalized benefit versus risk assessment; thera...

Journal: :Acta Crystallographica Section A Foundations and Advances 2014

Journal: :Disease models & mechanisms 2018
Allison R Rogala Alexi A Schoenborn Brian E Fee Viviana A Cantillana Maria J Joyce Raad Z Gharaibeh Sayanty Roy Anthony A Fodor R Balfour Sartor Gregory A Taylor Ajay S Gulati

Crohn's disease (CD) represents a chronic inflammatory disorder of the intestinal tract. Several susceptibility genes have been linked to CD, though their precise role in the pathogenesis of this disorder remains unclear. Immunity-related GTPase M (IRGM) is an established risk allele in CD. We have shown previously that conventionally raised (CV) mice lacking the IRGM ortholog, Irgm1 exhibit ab...

Journal: :EMBO reports 2011
Damien Arnoult Fraser Soares Ivan Tattoli Stephen E Girardin

Mitochondria are cellular organelles involved in host-cell metabolic processes and the control of programmed cell death. A direct link between mitochondria and innate immune signalling was first highlighted with the identification of MAVS-a crucial adaptor for RIGI-like receptor signalling-as a mitochondria-anchored protein. Recently, other innate immune molecules, such as NLRX1, TRAF6, NLRP3 a...

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