BACKGROUND MDM2 (Murine Double Minute2) is an oncoprotein that inhibits the P53 activity. Overexpression of MDM2 gene has been reported in several human tumors. In the present study, we aimed to evaluate the impact of 40-bp insertion/deletion (ins/del) polymorphism on the promoter of MDM2 and susceptibility to breast cancer in a sample of Iranian population. METHODS This case-control study wa...

Breast cancer (BC) is one of the most causes of death in women worldwide. It affects Iranian female population approximately a decade earlier than those in other parts of the world. Previous studies have shown that vascular endothelial growth factor (VEGF) gene variants were associated with BC risk. The current study aimed to evaluate the impact of VEGF rs3025039 (+936C>T), rs2010963 (+405C>G),...

Flap endonuclease 1 (FEN1), a DNA repair protein, is important in preventing carcinogenesis. Two functional germ line variants -69G>A (rs174538) and +4150G>T (rs4246215) in the FEN1 gene have been associated with risk of various types of cancer. The aim of the present study was to evaluate the possible impact of FEN1 polymorphisms on risk of breast cancer (BC) in a sample of Iranian subjects. T...

Although genetic variants that affect susceptibility to coronary artery disease (CAD) have been greatly known, a number of these single nucleotide polymorphisms (SNPs) remain to be analyzed in populations with different ethnicities. CAD is influenced by numerous genetic, environmental, and lifestyle factors, and is an important reason for mortality around the globe. In this study, a novel SNP (...

Uncertainty reduction underlies relational development, i.e., relationships develop as we learn more about each other. The present study examines ethnic differences in the uses of interactive uncertainty reduction communication--selfdisclosure, interrogative strategies, non-verbal immediacy, and other's self-disclosure-and their inter-relationships with attributional confidence (uncertainty red...

This article aims to bring a reflection on the theory of Social Representations from perspective Psychology. From bibliographic review, an analogy is made between theories social representations, concrete society, in this case, Mozambican society. representations have been topic widely discussed by several and categorized authors, many them addressing relationship cognition-knowledge, individua...

anthropometry is the study of human body dimensions and proportions among different races. in work environments, poorly designed workstations and tools reduce productivity and can lead to fatigue and musculoskeletal injuries. this study aimed to determine the anthropometric characteristics of iranian workers in comparison to three other asian countries. this cross-sectional study evaluated 400 ...

Iran is a country with different ethnicities and religions some negative experiences of conflicts throughout history. It believed that; Sports success factor in the greater convergence country's citizens. This article analyzes ethnic differences Iranian sports fans Islamic cohesion, national identity, perception success. The research was descriptive survey. statistical population all Iranians i...