The p53 protein is one of the major tumor suppressor proteins. In response to DNA damage, p53 is prevented from degradation and accumulates to high levels. Ionizing radiation leads to hypophosphorylation of the p53 ubiquitin ligase Mdm2 at sites where phosphorylation is critical for p53 degradation and to the phosphorylation and activation of Akt/PKB, a kinase that phosphorylates and inhibits G...

Autophagy has recently emerged as a significant mechanism in cancer treatment. Although gemcitabine and/or ionizing radiation are important modalities in the treatment of pancreatic cancer, the contribution of autophagy in such treatment has not been fully elucidated. This study investigated the role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation. To ...

Present review article describes use of radiation and radionuclides on cancer cell therapeutics. It also sketches out cumulative effects exposure received by the patients during diagnostics. Though, in therapeutics a selected permissible dose is provided several cycles to ablate neoplastic cells improve condition patient, but harms surrounding imparts negative biology cells. Ionizing (IR) promo...

radiography is one of the most valuable diagnostic tools used in comprehensive dental care. although there is no safe level of radiation exposure, the possible risk associated with exposure to radiation, must be elucidated. to date, a variety of assays have been proposed to assess the mutagenic potential of genotoxicants; however, these methods are typically laborious and time consuming. the ai...

conclusions the increasing cell toxicity, apoptosis-inducing effects and decreasing telomerase activity may play an important role in the valproic acid and radiation mechanism. the current survey suggested that it is likely beneficial to combine valproic acid and gamma radiation to treat breast cancer. results combination of valproic acid and gamma radiation increased significantly cell toxicit...

background: the aim of the study was to analyze the effective dose record of occupationally exposed radiation workers at bahawalpur institute of nuclear medicine and oncology department. materials and methods: annual effective doses of occupationally exposed workers were measured by film badge dosimetry by sending the dosimeters to radiation dosimetry laboratory (rdl), pakistan institute of nuc...

the protective effects of rheum tanguticum polysaccharide 1 (rtp1), which is extracted from the chinese traditional medicine rheum tanguticum, on radiation-induced intestinal mucosal injury was investigated. rat intestinal crypt epithelial cells (iec-6 cells) and sprague-dawley rats were each divided into control, irradiated and rtp1-pretreated irradiated groups. after irradiation, cell surviva...

Fractionated, high-dose total body irradiation (TBI) is used therapeutically to myeloablate and immune suppress patients undergoing hematopoietic stem cell (HSC) transplantation. Acute exposure to ionizing radiation can have fatal effects on the hematopoietic and immune systems. Currently, therapies aimed at ameliorating ionizing radiation-associated toxicities are limited. In the February 2014...

Introduction Radiation that has sufficient energy to remove electrons from atoms is called “ionizing radiation.” Ionization results in the production of negatively charged free electrons and positively charged ionized atoms. Ionizing radiation can be classified into two groups: photons (includes X-radiation and gamma radiation) and particles (includes alpha and beta particles and neutrons). The...

Ionizing radiation is electromagnetic radiation that has sufficient energy to remove electrons from atoms. Ionization results in the production of negatively charged free electrons and positively charged ionized atoms. Ionizing radiation can be classified into two categories: photons (X-radiation and gamma radiation) and particles (alpha and beta particles and neutrons). Five types or sources o...