the solubility of kno3 in the mixed solvent (water 85%+methanol 15%) were determined by using solvent evaporating method at different temperatures (25, 30, 40, 50, 60 ;c). in addition the equilibrium constant of ion pair formation, kip, for k+no3 – ion-pair on the basis of fuoss contact ion pair model was calculated. upon choosing the extended debye-hückel model for estimating the mean activity...

The solubility of KNO3 in the mixed solvent (water 85%+methanol 15%) were determined by using solvent evaporating method at different temperatures (25, 30, 40, 50, 60 ;C). In addition the equilibrium constant of ion pair formation, KIP, for K+NO3 – ion-pair on the basis of Fuoss contact ion pair model was calculated. Upon choosing the extended Debye-Hückel model for estimating the mean activity...

in this article, theoretical studies on the selective complexation of the halide ions (f¯, cl¯ and br¯) and ion pairs (na+f¯, na+cl¯ and na+br¯) with the cyclic nano-hexapeptide (cp) composed of l-proline have been performed in the gas phase. in order to calculate the dispersion interaction energies of the cp and ions, dft-d3 calculations at the m05-2x-d3/6-31g(d) level was employed. based on t...

a simple extractive spectrophotometric method has been developed for the estimation of miconazole nitratein both pure and pharmaceutical preparation. the method is based on the formation of ion-pair complex of thedrug with acidic dye bromothymol blue (btb) in acidic condition, followed by its extraction in organic solvent(chloroform). the absorbance was measured against the corresponding blank....

complexes of benzo-15-crown-5 macrocycle with li+ and cs+ ions were investigated by 7li and 133cs nmr in a number of nonoqueous solutions. the resulting 1:1 complex with li+ ion was found to be much more stable than that with cs+ ion. with the exception of pyridine solutions the stabilities of the complexes varied inversely with the gutmann donor number of the solvents. some indirect evidence f...

Ion-pairing is reported to improve the lipophilicity and subsequently the transport rate of polar drugs across lipid membranes. Lipophilisation of ionic drugs with high aqueous solubilities by ion-pair formation with appropriate counter-ion have proven to be promising for several applications. The aim of this review is to present the usefulness of ion-pair for improving the poor bioavailability...

The extraction and separation of copper(II), zinc(II), cobalt(II), and cadmium(II) were investigated. Both copper(II) and zinc(II) formed ammine-complexes, while cadmium(II) and cobalt(II) formed hydroxide precipitates in an ammonia medium. By the addition of sodium dodecylsulfate (SDS), a copper(II) complex formed an ion-pair (copper-ammine-DS), which was extracted into the SDS phase. However,...

The project report entitled, “ Charge Transfer Comlexes of drugs with  acceptors” is divided into two parts. Part-I deals with the spectrophotometric studies of molecular complexes of drugs with TCNE and Paraquat and Part II deals with Ion-pair charge transfer complexes of drugs with acidic triphenylmethane dyes. Each part is further divided into 1) Introduction 2) Experimental and 3) Results ...

Complexes of benzo-15-crown-5 macrocycle with Li+ and Cs+ ions were investigated by 7Li and 133Cs NMr in a number of nonoqueous solutions. The resulting 1:1 complex with Li+ ion was found to be much more stable than that with Cs+ ion. With the exception of pyridine solutions the stabilities of the complexes varied inversely w...

Clonidine hydrochloride is an antihypertensive agent used for migraine prophylaxis, attention deficit hyperactivity disorder, menopausal flushing and Tourette syndrome. The quantity of the active substance in pharmaceutical preparations must be within specific limits, in agreement with the respective label claim. Therefore, the aim of this study was to establish the conditions for two spectroph...