Traditionally, the spectrum acquired using ion mobility spectrometry (IMS) is an average of multiple experimental cycles. Each cycle is initiated by passing a short burst of ions into a drift tube containing a homogeneous electric field. Prior to starting the subsequent cycle, all ions in the system must arrive at the detector or spectral overlap may occur. To maximize resolution, the ion pulse...

A novel analytical method, called Liquid Phase Ion Mobility Spectrometry (LiPIMS) was demonstrated, where aqueous phase analytes were ionized and introduced into non-aqueous liquids, transported by an external electric field from the point of generation to a collection electrode. Ions were produced from a unique liquid phase ionization process, called Electrodispersion Ionization. Spectra of an...

The boronic acid derivatization of carbohydrates is demonstrated as an ion mobility shift strategy to improve confidence in the identification and characterization of carbohydrate assignments using ion mobility-mass spectrometry.

Ion mobility has a direct influence on the performance of conducting polymers in a number of applications as it dictates the operational speed of the devices. We report here the enhanced ion mobility of poly(3,4-ethylene dioxythiophene) after incorporation of gelatin. The gelatin-rich domains were seen to provide an ion pathway through the composites.

We demonstrate the isomer-resolved spectroscopy of gas-phase ions, with different geometries separated prior to spectroscopic probe using ion mobility techniques. Specifically, ring and chain isomers of carbon cluster anions with 10;-12 atoms have been separated by ion mobility/mass spectrometry and examined by photoelectron spectroscopy. This methodology should also apply to other ion spectros...

This paper reports the first example of electrospray ion mobility spectrometry as a detection method for HPLC separation, demonstrating its potential for the quantitative and selective detection of non-volatile and non-chromophoric organic compounds. Reduced mobility constants (Ko) for 21 carbohydrates, including simple sugars, sugar alcohols and amino sugars, were determined to range from 0.68...

A surface ionization (SI) source was designed and constructed for ion mobility spectrometry (IMS). Compared with a conventional (63)Ni source, the surface ionization source is as simple and reliable, has an extended dynamic response range, is more selective in response, and does not have regulatory problems associated with radioactive ionization sources. The performance of this SI-IMS was evalu...

Gas phase ion mobility measurements can resolve structural isomers for polyatomic ions and provide information about their geometries. A new experimental apparatus for performing high-resolution ion mobility measurements is described. The apparatus consists of a pulsed laser vaporization/desorption source coupled through an ion gate to a 63-cm-long drift tube. The ion gate is a critical compone...