We present herein a new and efficient four-component synthesis of isoxazol-5(2H)-ones involving ring closing/Knoevenagel condensation/Michael addition sequential reactions.

PURPOSE The purpose was to determine the effectiveness of the Tobacco Tactics program in three Veterans Affairs hospitals. METHODS In this effectiveness trial, inpatient nurses were educated to provide the Tobacco Tactics intervention in Ann Arbor and Detroit, while Indianapolis was the control site (N = 1,070). Smokers were surveyed and given cotinine tests. The components of the interventio...

m topography, drainage, and soil texture. Such homogeneity enabled the researchers to detect the effects of differing land-use on the structure and composition of the vegetation. Also motivating the study was the rarity of pitch pine-scrub oak communities. They support several rare plant and animal species but have been substantially degraded by industrial, commercial, and residential developme...

Although piano playing is a highly skilled task, basic features of motor pattern generation may be shared across tasks involving fine movements, such as handling coins, fingering food, or using a touch screen. The scripted and sequential nature of piano playing offered the opportunity to quantify the neuromuscular basis of coarticulation, i.e., the manner in which the muscle activation for one ...

Differences between exchange methods in exchange-only Kohn-Sham theory are highlighted by calculations of diatomic molecule total energies, uncoupled isotropic NMR shieldings, and HOMO-LUMO eigenvalue differences. Optimised effective potential (OEP) and Wu-Yang (WY) results are very similar. Localised Hartree-Fock (LHF) and Krieger-Li-Iafrate (KLI) results are close to one another, but are diff...

This study examined linkages between providing care for a parent (in contrast to not providing any care to other kin or nonkin) and four dimensions of physical health (self-rated health, functional limitations, physical symptoms, chronic conditions), as well as moderation of these linkages by gender and a negative dimension of marital quality--marital strain. Regression models were estimated us...

PURPOSE Wildland fires present many injury hazards to firefighters. We estimate injury rates and identify fire-related factors associated with injury. METHODS Data from the National Interagency Fire Center from 2003 to 2007 provided the number of injuries in which the firefighter could not return to his or her job assignment, person-days worked, and fire characteristics (year, region, season,...

What does The Haywain represent? Or Mondrian's Broadway Boogie Woogie? How about Rothko's Red on Maroon? In the case of the Constable painting, the answer seems straightforward, and we can even visit the site of the scene he sketched (more or less). Mondrian, rejecting the distinction between abstract and representational art, himself suggested that his work represented structure. But with Roth...

AIMS Pigmented villonodular synovitis (PVNS) is a rare, locally aggressive and potentially recurrent synovial disease. We present the largest single-centre experience of knee PVNS. Our aim was to evaluate our tertiary hospital's experience in the management of knee PVNS. PATIENTS AND METHODS Retrospective data collection of consecutive cases of knee PVNS from 2002 to 2015. RESULTS In total,...