نتایج جستجو برای: intravitreal

تعداد نتایج: 6980  

2015
Pravin U Dugel Francesco Bandello Anat Loewenstein

Diabetic macular edema (DME) resembles a chronic, low-grade inflammatory reaction, and is characterized by blood-retinal barrier (BRB) breakdown and retinal capillary leakage. Corticosteroids are of therapeutic benefit because of their anti-inflammatory, antiangiogenic, and BRB-stabilizing properties. Delivery modes include periocular and intravitreal (via pars plana) injection. To offset the s...

Journal: :Archives of ophthalmology 2001
G Velez P Yuan C Sung G Tansey G F Reed C C Chan R B Nussenblatt M R Robinson

OBJECTIVE To investigate the pharmacokinetics and toxicity of intravitreal chemotherapeutic agents in the rabbit eye for the potential treatment of primary intraocular lymphoma and other intraocular malignancies. METHODS The ocular pharmacokinetics of intravitreal methotrexate sodium (400 microg) was studied in 10 New Zealand white rabbits, and a single-compartment, first-order elimination mo...

2011
Biju John

Man’s invasion into the sacred inner space of the eyethe vitreous cavity began around the same time he was attempting to invade the outer space i.e. in the 1950s. Von Sallman in1944 demonstrated the efficacy of Intravitreal antibiotics in a study in which he successfully cured endophthalmitis in rabbits by Intravitreal Penicillin injection. And thus began the era of Intravitreal antibiotics. Fi...

2017
Amelie Pielen W Lloyd Clark David S Boyer Yuichiro Ogura Frank G Holz Jean-Francois Korobelnik Brigitte Stemper Friedrich Asmus Kay D Rittenhouse Christiane Ahlers Robert Vitti Namrata Saroj Oliver Zeitz Julia A Haller

OBJECTIVES To report on the efficacy and safety of intravitreal aflibercept in patients with macular edema secondary to central retinal vein occlusion (CRVO) in an integrated analysis of COPERNICUS and GALILEO. PATIENTS AND METHODS Patients were randomized to receive intravitreal aflibercept 2 mg every 4 weeks or sham injections until week 24. From week 24 to week 52, all intravitreal afliber...

Journal: :journal of current ophthalmology 0
مهدی مدرس mehdi modarres حسین نظری hossein nazari مژگان رضایی کنوی mozhgan rezaei-kanavi امین ا... نیک اقبالی aminollah nikeghbali خلیل قاسمی فلاورجانی khalil ghasemi falavarjani مصطفی سلطان سنجری mostafa soltan sanjari کاوه ابری اقدم

purpose : to determine the maximum non-toxic dose of recombinant human erythropoietin (epo) in rabbit eyes methods : eight rabbits (sixteen eyes) were scheduled for evaluating side effects of four intravitreal doses of 1000, 2000, 4000 and 5000 iu of epo, two rabbits for each dose. for each dose (two rabbits), the drug was injected for the right eyes. balanced salt solution (bss) was injected i...

Journal: :journal of current ophthalmology 0
حسین نظری hossein nazari مهدی مدرس زاده mehdi modarreszadeh محسن بهمنی کشکولی mohsen bahmani-kashkouli مسعود ناصری پور masoud naseripour محمدمهدی پرورش mohammad-mehdi parvaresh پریدخت نظری paridokht nazari

purpose: to study the pattern of perfusion of central retinal artery (cra) after 0.1 ml intravitreal injection of bevacizumab to verify the need for any maneuver to decrease the intraocular pressure (iop) including anterior chamber paracentesis (acp) methods: this is a prospective, interventional, noncomparative case series. patients receiving intravitreal injection of bevacizumab for choroidal...

Journal: :بینا 0
علی کثیری a kasiri ahvaz jondi shapoor university of medical sciences, ahvaz, iranاهواز-خیابان آزادگان-بیمارستان امام خمینی (ره)-بخش چشم پزشکی مصطفی فقهی m feghhi ahvaz jondi shapoor university of medical sciences, ahvaz, iranاهواز-خیابان آزادگان-بیمارستان امام خمینی (ره)-بخش چشم پزشکی فریناز برنا f borna ahvaz jondi shapoor university of medical sciences, ahvaz, iranاهواز-خیابان آزادگان-بیمارستان امام خمینی (ره)-بخش چشم پزشکی بهمن چراغیان b cheraghian ahvaz jondi shapoor university of medical sciences, ahvaz, iranاهواز-خیابان آزادگان-بیمارستان امام خمینی (ره)-بخش چشم پزشکی

purpose: to evaluate the effects of intravitreal and intracameral injection of bevacizumab in patients with neovascular glaucoma (nvg).   methods: this interventional case series was conducted on 40 eyes of 40 patients with neovascular glaucoma. data included the extent of iris (nvi) and angle neovascularization (nva), peripheral anterior synechia (pas), and intraocular pressure (iop). followin...

Journal: :journal of current ophthalmology 0
محمدصادق فره وش mohammad-sadegh farahvash مسعود اقصائی فرد masood aghsaie-fard احمد میرشاهی ahmad mirshahi علیرضا لاشیئی alireza lashay احمد جوادیان ahmad javadian هوشنگ فقیهی hooshang faghihi مرضیه مرادی مقدم

purpose: to compare the effect of tissue plasminogen activator (tpa) and aspirin in patients with central retinal vein occlusion. methods: a prospective interventional study was conducted on patients with central retinal vein occlusion of less than 28 days' duration. patients in the tpa group received 100 μg intravitreal tissue plasminogen activator and the patients who declined intravitre...

Journal: :بینا 0
سیدمهدی مدرس زاده m modareszadeh ophthalmic research center, iran university of medical sciences, tehran, iranتهران- خیابان ستارخان- خیابان نیایش- بیمارستان حضرت رسول اکرم (ص)- مرکزتحقیقات چشم مژگان رضایی کنوی m rezaie kanavi ophthalmic research center, shahid beheshti university of medical sciences, tehran, iranدانشگاه علوم پزشکی شهید بهشتی حسین نظری h nazari ophthalmic research center, iran university of medical sciences, tehran, iranتهران- خیابان ستارخان- خیابان نیایش- بیمارستان حضرت رسول اکرم (ص)- مرکزتحقیقات چشم خلیل قاسمی فلاورجانی kh ghasemi falavarjani ophthalmic research center, iran university of medical sciences, tehran, iranتهران- خیابان ستارخان- خیابان نیایش- بیمارستان حضرت رسول اکرم (ص)- مرکزتحقیقات چشم عادل قاسم پور a ghasempoor ophthalmic research center, iran university of medical sciences, tehran, iranتهران- خیابان ستارخان- خیابان نیایش- بیمارستان حضرت رسول اکرم (ص)- مرکزتحقیقات چشم

purpose: to evaluate the safety of different doses of intravitreal bevacizumab in rabbit eyes. methods: twelve eyes of 6 rabbits underwent intravitreal injection of 5, 7.5 and 10 mg of bevacizumab. in each rabbit, one eye was considered for bevacizumab injection and the fellow eye served for either placebo injection or observation. all eyes were examined before and 1, 2, 3, 7, 14 and 28 days af...

Journal: :Archives of ophthalmology 2005
Rodney S Bucher Edward Hall David M Reed Julia E Richards Mark W Johnson David N Zacks

OBJECTIVES Recent reports of high endophthalmitis rates after intravitreal triamcinolone acetonide injection have raised concerns about the safety of this treatment. We sought to evaluate the effect of intravitreal triamcinolone injection on (1) the susceptibility to experimental bacterial endophthalmitis and (2) the subsequent therapeutic response to antibiotic treatment. DESIGN For the susc...

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