Hydroxychloroquine (HCQ), a drug used to treat many diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), has limited reports documenting drug-induced myopathies side effect. This entity is underdiagnosed with unclear treatment interventions apart from discontinuing the offending drug. We report case of biopsy-proven hydroxychloroquine-induced myopathy in 35-year-ol...

previous, intravenous immunoglobulin (ivig) has been used for treatment of patients with immunodeficiency. however, recent studies have shown that ivig is a suitable approach for treatment of inflammatory and autoimmune diseases. although the exact mechanism of ivig action is not well known, recent findings have demonstrated that ivig impacts on expression and function of fc receptors of immuno...

previous, intravenous immunoglobulin (ivig) has been used for treatment of patients with immunodeficiency. however, recent studies have shown that ivig is a suitable approach for treatment of inflammatory and autoimmune diseases. although the exact mechanism of ivig action is not well known, recent findings have demonstrated that ivig impacts on expression and function of fc receptors of immuno...

Abstract Intravenous immunoglobulins (IVIg) have been used in clinical practice for more than 50 years. They are dermatological indications such as dermatomyositis, pemphigus and Kawasaki disease. Although this is regarded a safe treatment modality, it can produce adverse reactions the skin. We report two patients with IVIg-induced skin changes. A 71-year-old man no preceding disease was under ...

In Guillain-Barré syndrome, the body's immune system attacks part of peripheral nervous system. We present a case series four cases with different variants. Three have been diagnosed nerve conduction studies, one positive lumbar puncture test albumino-cytological dissociation. Each patient was treated Intravenous Immunoglobulin (IVIG) and improved clinically. This is being delivered in order to...

Background: Mild to severe post-transfusion adverse reactions have been reported in a proportion of immunodeficient patients receiving intravenous immunoglobulin (IVIg). Anti-IgA antibody has been proposed to be associated with development of such reactions. Objective: To assess the association between anti-IgA levels of different isotypes and adverse reactions induced in immunodeficient patien...

hyper-igm syndromes are characterized by profound reduction of serum igg, iga, and ige levels with normal or increased concentrations of serum igm. cd40 ligand deficiency is x-linked form of the disease, which results in a lack of immunoglobulin class switching from igm to igg in b cells. in addition to the recurrent infections, a number of patients suffer from neutropenia. there are some evide...

Background: Epidermolysis bullosa aquisita (EBA) is a severe acquired blistering skin disease that is often resistant to prednisolone but can respond well to intravenous immunoglobulin infusion (IVIg). Main Observations: We describe the case of a 35 years old male patient with EBA who developed clinically significant haemolytic anaemia with a drop in Hb from 15.3 g/dL to a nadir of 8.4 g/dL wit...

Intravenous immunoglobulin (IVIG) is an expensive medicine which is widely used for unlabeled indications. We conducted this drug utilization review (DUR) to evaluate the appropriateness of IVIG utilization in Tehran, Iran. This cross sectional study was conducted in a referral pediatric tertiary care hospital in Tehran. During a three month period in 2015, medical records of inpatients with IV...

Intravenous immunoglobulin (IVIG) is used to treat several autoimmune and inflammatory diseases, but some patients are refractory IVIG require alternative treatments. Identifying a biomarker that could segregate responders from non-responders has been subject of intense research. Unfortunately, previous transcriptomic studies aimed at addressing resistance have failed predict identify IVIG-non-...