Alemtuzumab is a humanized anti-CD52 antibody licensed for refractory B-cell chronic lymphocytic leukemia (B-CLL), when given intravenously at 30 mg thrice weekly. However, the intravenous route is associated with infusion-related reactions and is inconvenient. We measured blood concentrations in 30 relapsed patients treated with intravenous alemtuzumab and in 20 patients from a previously untr...

introduction: intravenous drug users as a serious health problem in communities have economical and social effects as well as health and hygienic complications. viral infections may be transmitted through drug injection by shared syringes among users. the aim of this study has been to determine the relative frequency of hbv, hcv and hiv infection’s markers as epidemiological data in ahvaz. mate...

introduction: due to its immunosuppressive properties, local graft irradiation (lgi) has been proposed as a second line therapy for treatment of acute kidney rejection. case presentation: in this case-series we report 6 patients with biopsy proven acute kidney allograft rejection refractory to conventional antirejection therapy who underwent lgi for treatment of acute rejection at our center. t...

bakcground: the aim of itp treatment is to prevent intracranial hemorrhage and increase the platelet count rapidly. this study was conducted with the objective of comparing the efficacy of anti-d immunoglobulin (ig) with dexamethasone in treating childhood itp. materials and methods: in this randomized prospective control trial, 20 itp patients (platelet count< 20,000/µl) younger than 16 were s...

Abstract Hemolytic disease of the fetus and newborn (HDFN) remains main cause fetal anemia primarily due to RH-D maternal incompatibility but also other rarer antigens. Anti-Kell mediated immunization is a rare involving about 0.1% pregnant women causing more severe HDFN compared both for its mechanism because lack preventive immunoglobulin therapy. Although standard treatment intrauterine tran...

OBJECTIVES Previous studies have examined renal safety of once daily intravenous tobramycin in individuals with cystic fibrosis. This has been mainly in combination with ceftazidime in an adolescent or adult population. In this report, we describe our institutional experience of once daily intravenous tobramycin in combination with a variety of second anti-pseudomonal antibiotics in children wi...

BACKGROUND AND OBJECTIVE Numerous drugs have been used to prevent or to treat opioid-induced pruritus in the surgical setting. Their relative efficacy is not well understood. METHODS The methods employed involved the systematic search (MEDLINE, EMBASE, Cochrane library, bibliographies, without language restriction, up to June 2000) for full reports of randomized comparisons of any interventio...