two siblings (a girl and a boy) with intrauterine growth retardation and earlyonset insulin dependent diabetes mellitus, who had a clinical syndrome consistent with' congenital pancreatic hypoplasia will be reported.

The outcome of early small-for-gestational age and/or intrauterine growth-restricted fetuses is reviewed. In these fetuses the outcome appears to be considerably poorer than that of appropriately grown fetuses and this seems mainly to be caused by intrauterine malnutrition rather than by hypoxemia. Active management of intrauterine growth restriction at the limits of viability may not be commen...

US pregnant uterus 9 Assessment of fetal measurement, growth, amniotic fluid, fetal anatomic survey, and activity patterns is appropriate. O US pregnant uterus biophysical profile 4 Assessment of biophysical profile is of indeterminate appropriateness. Biophysical profile components: 1) fetal heart-rate reactivity; 2) fetal breathing movements; 3) fetal movement; 4) fetal tone; and 5) amniotic ...

Hormones are both growth stimulatory and growth inhibitory in utero. They regulate tissue growth and development by controlling the rates of cell proliferation, apoptosis and differentiation in many fetal tissues. They also signal the level of resources available for intrauterine growth to the fetal tissues and relay back to the placenta the degree of mismatch between the actual fetal nutrient ...

OBJECTIVE Low birth weight is associated with diabetes in adult life. Accelerated or "catch-up" postnatal growth in response to small birth size is thought to presage disease years later. Whether adult disease is caused by intrauterine beta-cell-specific programming or by altered metabolism associated with catch-up growth is unknown. RESEARCH DESIGN AND METHODS We generated a new model of int...

Intrauterine growth restriction is associated with increased risk for adult metabolic syndrome and cardiovascular disease, which seems to be related to altered food preferences in these individuals later in life. In this study, we sought to understand whether intrauterine growth leads to fetal programming of the hedonic responses to sweet. Sixteen 1-day-old preterm infants received 24% sucrose ...

Two siblings (a girl and a boy) with intrauterine growth retardation and earlyonset insulin dependent diabetes mellitus, who had a clinical syndrome consistent with' congenital pancreatic hypoplasia will be reported.