Background and objectives: The molecular mechanism of hypotension post spinal anesthesia is unknown. This study hypothesized that the sympathectomy from spinal anesthesia would cause an increase in nitric oxide (NO) levels. Methods: 36 ASA 1 or 2 patients undergoing extracorporeal shock wave lithotripsy were prospectively enrolled. Plasma levels of NO reaction products were measured pre and pos...

BACKGROUND Clinical investigations have reported several anesthetic properties of intrathecal injections of meperidine. The purpose of this study was to investigate the effect of adding meperidine to intrathecal heavy lidocaine on hemodynamic changes and blood loss in patients undergoing elective suprapubic open prostatectomy. METHODS In a randomized double-blind clinical trial, 77 patients c...

PURPOSE To determine whether the use of intrathecal sufentanil, which allows the patient to move during shockwave lithostripsy (SWL), affects treatment outcomes and operative and recovery times compared with standard lidocaine spinal anesthesia. PATIENTS AND METHODS We retrospectively studied a series of 62 SWL procedures performed on an unmodified Dornier HM3 lithotripter. The mean calculus ...

the quality of subarachnoid block can be improved by adding opioids to the local anesthetics. we compared the analgesic effects of different doses of intrathecal sufentanil added to lidocaine %5 for elective cesarean section. this study was a prospective, randomized, double-blind, controlled trial. 90 pregnant women with asa class i-ii, scheduled for elective cesarean section under spinal anest...

BACKGROUND Postherpetic neuralgia (PHN) is a complication of acute herpes zoster, which is emerging as a preferred clinical trial model for chronic neuropathic pain. Although there are published meta-analyses of analgesic therapy in PHN, and neuropathic pain in general, the evidence base has been substantially enhanced by the recent publication of several major trials. Therefore, we have conduc...

Objective: In order to prolong the duration of intrathecal lidocaine, various drugs are used along with it. Due to the promising effects of tizanidine on central nervous system, it can be assumed that tizanidine can have a positive effect on increasing the anesthesia duration too. Thus, we aimed to investigate the effect of oral tizanidine on the duration of lidocaine spinal anesthesia.Me...

Main results 27 trials were included. 6 trials evaluated topical treatments (follow up of 2 d to 6 wk). Of 2 trials that compared a lidocaine patch with placebo, 1 showed no difference and 1 showed a reduction in pain with lidocaine. 2 trials showed greater pain relief with capsaicin 0.075% cream than with placebo. 2 trials comparing benzydamine cream with placebo showed no difference between g...

A 43-year-old woman had trigger-point injections for chronic neck pain by a traditional Chinese medicine physician. Paravertebral muscles at C5-C6 were infiltrated with lidocaine. Thirty minutes later, right-sided hemiparesis with nystagmus, dysarthria, and anisocoria developed. The patient complained of vertigo, vomited multiple times, and became somnolent. Neuroimaging revealed air in the ven...

The application of lidocaine can lead to nerve damage. Evidence suggests that patients with diabetic neuropathy are at a higher risk for neurotoxicity. In the present study, the successful induction of diabetic neuropathic pain (DNP) in rats via a high-sugar, high-fat diet and intraperitoneal injection of 1% streptozotocin was verified and pronounced tactile allodynia was observed. It was found...

aim and background:   hypotension and nausea are common side effects during spinal anesthesia. this study compared the incidence of hypotension and nausea-vomiting induced by bupivacaine and lidocaine in parturients undergoing caesarean section under spinal anaesthesia. methods and materials:   in this clinical trial, 120 parturients undergoing caesarean section were randomly allocated into two...