Aim: To analyse the effect of combination intranasal corticosteroid and antihistamine spray in patients suffering from proven Allergic Rhinitis who have failed primary care therapy. Background: Allergic Rhinitis is prevalent in the community and worldwide, with a rising trend, it also impacts on health related quality of life, sleep and (in appropriate age groups) school attendance. Method: The...

introduction: preoperative psycho emotional preparation of patients is one of the principle purposes of anesthesia which can be achieved by administration of premedications. children should receive premedication before entering the operating room due to their dependence on parents and the fear and anxiety of separation from parents. different drugs are administered for this purpose, but conside...

Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) and severe eosinophilic asthma (SEA) are common comorbidities characterised by type 2 inflammation associated increased expression of interleukin 5. Methods: Eight patients SEA CRSwNP attended the Scottish Centre for Respiratory Research as part a clinical trial (EudraCT number 2019-003763-22). Following an initial 4-week run-in pe...

A novel intranasal formulation of azelastine HCl (AZE, an antihistamine) and fluticasone propionate (FP, a corticosteroid) in a single spray (MP-AzeFlu [Dymista®]) was studied in four randomized, double-blind, placebo-controlled trials of patients with seasonal allergic rhinitis conducted in the US. Study sites were distributed so that all major US geographic regions and the prevalent pollens w...

Of the classes of pharmacotherapy for seasonal allergic rhinitis, intranasal corticosteroids are the preferred treatment and are recommended in practice guidelines as first-line pharmacotherapy for rhinitis with prominent nasal congestion. The enhanced-affinity intranasal corticosteroid fluticasone furoate nasal spray (GW685698X), is one of the newest additions to the armamentarium for allergic...

OBJECTIVES/HYPOTHESIS Postendoscopic sinus surgery corticosteroid administration reduces polyp formation, inflammation, and adhesions. Steroid-eluting bioabsorbable intranasal devices (SEBID) are novel interventions thought to improve local drug delivery while minimizing systemic side effects. The primary aim of this systematic review is to evaluate the efficacy and safety of bioabsorbable SEBI...