BACKGROUND Intrahepatic cholestasis of pregnancy is associated with an increased risk of fetal death. The mechanism of death is unknown. CASES The first case involved a young primipara with pruritus and a bile acid concentration of 79 mumol/dL. While undergoing fetal heart rate monitoring, the fetus had a prolonged deceleration resulting in intrauterine death. The second case involved a young...

UNLABELLED Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease, characterized by maternal pruritus and raised serum bile acids. Our objectives were to describe the epidemiology and pregnancy complications associated with severe ICP and to test the hypothesis that adverse perinatal outcomes are increased in these women. A prospective population-based case-control st...

Intrahepatic cholestasis of pregnancy commonly presents in the second and third trimester with unexplained pruritus sine materia, abnormal liver function tests, and/or elevated serum total bile acid concentration. Its incidence ranges from less than 1% to 27.6%, Araucana Indians Chile being highest affected. complicates pregnancy, hence influencing its outcomes. Our series involves three cases ...

OBJECTIVE To describe the use of combined ursodeoxycholic acid (UDCA) and rifampicin treatment in intrahepatic cholestasis of pregnancy (ICP). STUDY DESIGN A questionnaire survey of 27 women with 28 affected pregnancies identified via the UK and International Obstetric Medicine forum. The clinical case notes of women with ICP treated with combined UDCA and rifampicin therapy were reviewed, an...

Itching is a common complaint in pregnancy, occurring in up to 14 to 23% of women. Pruritus may be so severe that it affects sleep and quality of life. It has a prevalence of 0.7 to 5% in different populations.1 Prevalence is influenced by genetic and environmental factors and varies between populations worldwide. In Chile, 2.4% of all pregnancies are affected with a 5% prevalence in women of A...

Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require l...

Objective: To determine the perinatal outcome of intrahepatic cholestasis pregnancy and its association with obstetric biochemical parameters.
 Study Design: cross-sectional study.
 Place Duration Study: Pak Emirates Military Hospital, Rawalpindi, from Feb to Aug 2020.
 Methodology: Among 3201 patients, 50 patients were included in study. Data was collected on a well-designed pro...