Heejung Mo, Hyung-Min Kwon, Jae-Sung Choi, Seon Jae Ahn, Yong-Seok Lee Department of Neurology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea Department of Neurology, Seoul National University Hospital, Seoul, Korea c Department of Thoracic and Cardiovascular Surgery, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seo...

OBJECTIVE IA therapy with hyaluronan (HA) is reported to provide symptomatic relief and disease modification in OA. This study assessed the pathological changes in the synovium of an ovine model of OA and evaluated the effects of two HA preparations on this pathology. METHODS Eighteen sheep had bilateral lateral meniscectomy to induce OA. Four months post-surgery animals received IA saline or...

Pathology of antibiotic-treated human heart valve allografts. Forty-two human heart valves treated with an antibiotic solution were examined by light and electron micro-scopy up to 168 weeks after grafting in aortic, mitral, and tricuspid positions. There was a progressive degeneration of donor cells and by 40 days both fibroblasts and endothelial cells had vanished, leaving grafts virtually ac...

BACKGROUND Previous pathological and clinical studies demonstrated an intimal defect in patients with acute aortic intramural hematoma (IMH). The purpose of this study was to investigate the prevalence and clinical outcome of intimal defect detected by multidetector computed tomography (MDCT) in patients with IMH. METHODS AND RESULTS We retrospectively analyzed 38 consecutive patients with IM...

The formation of a neointima represents an important repair mechanism in response to vascular injury. It is associated with the expression of a specific set of genes by the intimal smooth muscle cells. Recently, expression of the inducible isoform of NO synthase (iNOS) has been identified in injured arteries during neointimal formation, suggesting that intimal SMCs have a unique mechanism for r...

We studied 986 patients who underwent follow-up angiography after successful percutaneous transluminal coronary angioplasty (PTCA) to determine the influence of uncomplicated intimal dissection on restenosis rate. Angiographic evidence of intimal dissection after PTCA was present in 248 patients or 25%. After a mean follow-up time of 7 +/- 5 months (SD) the restenosis rate in patients without i...

BACKGROUND Transcatheter balloon aortic valvuloplasty for critical aortic stenosis in neonates is routinely performed without recognized complication. Aortic wall injury has rarely been observed after balloon aortic valvuloplasty, although the incidence of this complication is unstudied. We reviewed single-center data to determine the incidence of aortic injury during balloon aortic valvuloplas...

The formation of a neointima represents an important repair mechanism in response to vascular injury. It is associated with the expression of a specific set of genes by the intimal smooth muscle cells. Recently, expression of the inducible isoform of NO synthase (iNOS) has been identified in injured arteries during neointimal formation, suggesting that intimal SMCs have a unique mechanism for r...

Weninger and colleagues, 1 in this issue of Circulation Research, have simply and elegantly reported on a piece of fundamental arterial biology totally unexplored before: the developmental origins of the intima in the siphon of the internal carotid artery. This site was chosen for study because the parasellar internal carotid artery in adults has the unwelcome fate of being highly prone to athe...