INTRODUCTION: Bulging of the intervertebral discs during normal motion of the spine has been proposed as a potential cause of pain through either compression of the spinal cord or impingement of exiting neural elements. Although past studies have characterized both normal and stenotic dimensions of the spinal canal and intervertebral foramen, no previous study has described the amount of disc o...

Because extrafibrillar water content dictates extrafibrillar osmolarity, we aimed to determine the influence of intra- and extrafibrillar fluid exchange on intradiscal pressures and stresses. As experimental results showed that extrafibrillar osmolarity affects intervertebral disc cell gene expression and crack propagation, quantification of the effects of changes in intra- and extrafibrillar f...

Intervertebral disc degeneration is a primary cause of low back pain and has a high societal cost. The pathological mechanism by which the intervertebral disc degenerates is largely unknown. Cell-based therapy especially using bone marrow mesenchymal stem cells as seeds for transplantation, although still in its infancy, is proving to be a promising, realistic approach to intervertebral disc re...

BACKGROUND Canine intervertebral disc degeneration can lead to intervertebral disc disease. Mild degenerative changes in the structure of the canine intervertebral disc can be identified in magnetic resonance images, whereas these changes are not visible in computed tomographic images. Therefore, one aim of this study was to detect whether colour-coded computed tomography enhances the visibilit...

PURPOSE Currently, no studies exist, which attest the suitability of the ovine intervertebral disc as a biomechanical in vivo model for preclinical tests of new therapeutic strategies of the human disc. By measuring the intradiscal pressure in vivo, the current study attempts to characterize an essential biomechanical parameter to provide a more comprehensive physiological understanding of the ...

The goal of the study is to show the histological and biochemical changes that indicate the angiogenesis of the intervertebral disc in lumbar intervertebral disc hernia and the existence of epidemiological correlations between these changes and the risk factors of lumbar intervertebral disc hernia, as well as the patient's quality of life (QOL). We have studied 50 patients aged between 18 and 7...

background: spine of an adult is made up of five areas that include 7 cervical vertebrae, 12 thoracic vertebrae, 5 lumbar vertebrae, sacrum and finally coccyx. selecting appropriate assumptions for modeling and biological analysis of the spine components has a significant impact on the accuracy of results in biomechanical simulation for different modes. methods: in the present study, biomechani...

STUDY DESIGN An in vitro biomechanical investigation in the human lumbar spine focuses on the functional significance of vertebral bone density and intervertebral disc degenerations. OBJECTIVE To determine that interrelationship between vertebral bone density and intervertebral disc degeneration, their effect on normal spine motion, and their significance in the biotechnical performance of in...

Low back pain secondary to degenerative intervertebral disc disease contributes to significant pain and disability in the United States. The potential to reverse intervertebral disc degeneration has driven significant interest in the development of stem cell therapy for degenerative disc disease. Early animal models have demonstrated that stem cell therapy may facilitate the reversal of the dis...

OBJECTIVE To evaluate the correlation between the severity of intervertebral disc injury and the anteroposterior type of thoracolumbar vertebral fractures. METHODS Fifty-six cases of thoracolumbar vertebral fractures treated in our trauma center from October 2012 to October 2013 were included in this study. The fractures were classified by the anteroposterior classification, whereas the sever...