In this study, a novel interpenetrating polymer network (IPN) hydrogel composed of crosslinked sodium alginate and poly(acryl acid) was prepared for transdermal delivery of an antihypertensive drug, prazosin hydrochloride. Due to the reversible swelling behavior of the hydrogels, the synthesized networks can sense the environmental pH change and achieve an oscillatory release pattern. Using dru...

Abstract III AbstractIII Abstract The integration of modeling, simulation and optimization provides powerful tools for supporting advanced decision making in the competitive market. However, when applying the tools to polymerization processing, the challenging task is to accommodate the predictability of the mathematical model and the capability of model-based optimization due to its inherent c...

Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The hydrogel surface morphology and composition were characterized by Fourier trans...

Development of a controllable polymer system using interpenetrating networks" (2013). My research partners and I have studied the possibility of building a material system with controllable properties using two interpenetrating polymer networks (IPNs). This study is part of a project to build a rapid prototyping system that allows for the printing of objects with predefined spatial distribution...