IMPORTANCE Early adversity is an important risk factor that relates to internalizing symptoms and altered brain structure. OBJECTIVE To assess the direct effects of early adversity and child internalizing symptoms (ie, depression, anxiety) on cortical gray matter (GM) volume, as well as the extent to which early adversity associates with variation in cortical GM volume indirectly via increase...

OBJECTIVE Fetal exposure to maternal prenatal stress hormones such as cortisol exerts influences on the developing nervous system that persist and include risk for internalizing symptoms later in life. Placental corticotropin-releasing hormone (pCRH) is a feto-placental stress signal that also shapes fetal neurodevelopment and may be a more direct indicator of the fetal experience than maternal...

An integration of family systems perspectives with developmental psychopathology provides a framework for examining the complex interplay between family processes and developmental trajectories of child psychopathology over time. In a community sample of 98 families, we investigated the evolution of family relationships, across multiple subsystems of the family (i.e., interparental, mother-chil...

The present study examined the association between covert narcissism and internalizing symptoms (i.e., shame, anxiety) in adolescents following an ego threat. Participants were 132 adolescents (101 males, 30 females, 1 not reported), ages 16–19 (M = 16.81 years, SD = .81), attending a residential program. Participants were randomly assigned to one of three feedback conditions (i.e., positive, n...

Multiple behavioral and health outcomes, including internalizing symptoms, may be predicted from prenatal maternal anxiety, depression, or stress. However, not all children are affected, and those that are can be affected in different ways. Here we test the hypothesis that the effects of prenatal anxiety are moderated by genetic variation in the child's brain-derived neurotrophic factor (BDNF) ...

Peer victimization experiences represent developmentally salient stressors among adolescents and are associated with the development of internalizing symptoms. However, the mechanisms linking peer victimization to adolescent psychopathology remain inadequately understood. This study examined emotion dysregulation as a mechanism linking peer stress to changes in internalizing symptoms among adol...

Internalizing disorders refer to a range of anxious and depressive behaviors in which individuals direct their feelings and emotions inward. Nearly 10% of children meet the diagnostic criteria for at least one internalizing disorder by age 16. Given that symptoms of depression and anxiety in childhood are predictors of a full diagnosis of depression or anxiety disorders in adulthood, it is impo...

Objective To examine the aspects of parenting stress-parental distress [PD] and parental stress due to dysfunctional interactions [PSDI]-reported by mothers of girls with attention-deficit/hyperactivity disorder (ADHD) in both childhood and adolescence and to understand their associations with internalizing and externalizing symptoms in adolescence. Design The diverse sample comprised 120 gir...

Mechanisms that account for treatment effects are poorly understood. The current study examined processes that may underlie treatment outcomes of an attachment-based intervention (Connect) for parents of pre-teens and teens with serious behavior problems. Parents (N = 540) in a non-randomized trial reported on their teen's functioning prior to and following treatment. Results confirmed signific...

Vagal tone is a measure of cardiovascular function that facilitates adaptive responses to environmental challenge. Low vagal tone is associated with poor emotional and attentional regulation in children and has been conceptualized as a marker of sensitivity to stress. We investigated whether the associations of a wide range of psychosocial stressors with internalizing and externalizing psychopa...