Abstract Canine atopic dermatitis (CAD) is a prevalent genetically susceptible inflammatory and pruritic allergic skin condition affecting not only the health of dogs but also quality life their owners. Interleukin-31 (IL-31) interleukin-31 receptor alpha (IL-31RA) are essential for development pruritus in primates mice. Hence, it expected that inhibiting IL-31RA will be an effective approach t...