نتایج جستجو برای: interleukin 23

تعداد نتایج: 280903  

Journal: :Genetics and molecular research : GMR 2014
Y K Kang M C Zhang

The aim of this study was to determine the effect of IL-23 on the activity and proliferation of osteoclasts (OC) in co-culture with osteoblasts (OB). OB and OC were individually separated from the skull and femoral bone of a SD rat. OB-OC co-culture with IL-23 added was designed as the experimental group, while the OB-OC co-culture without IL-23 was the control group. In the experimental group,...

2013
Hui Shen Wei Zhang Clara Abraham Judy H. Cho

The interleukin-23 (IL-23) pathway plays a critical role in the pathogenesis of multiple chronic inflammatory disorders, however, inter-individual variability in IL-23-induced signal transduction in circulating human lymphocytes has not been well-defined. In this study, we observed marked, reproducible inter-individual differences in IL-23 responsiveness (measured by STAT3 phosphorylation) in p...

2010
Philip P. Ahern Chris Schiering Sofia Buonocore Mandy J. McGeachy Dan J. Cua Kevin J. Maloy Fiona Powrie

Mutations in the IL23R gene are linked to inflammatory bowel disease susceptibility. Experimental models have shown that interleukin-23 (IL-23) orchestrates innate and T cell-dependent colitis; however, the cell populations it acts on to induce intestinal immune pathology are unknown. Here, using Il23r(-/-) T cells, we demonstrated that T cell reactivity to IL-23 was critical for development of...

Journal: :Journal of immunology 2010
Lorena Riol-Blanco Vanja Lazarevic Amit Awasthi Meike Mitsdoerffer Brian S Wilson Andy Croxford Ari Waisman Vijay K Kuchroo Laurie H Glimcher Mohamed Oukka

IL-23 plays an important role in autoimmune tissue inflammation and induces the generation of not fully characterized effector cells that mediate protection against pathogens. In this paper, we established the essential role of IL-23R in the host response against intracellular pathogens. IL-23 was critical for the expansion or maintenance of gammadelta and double negative (DN) alphabeta T cells...

Journal: :The Journal of biological chemistry 2011
Anna von Rossum Randall Krall Nichole K Escalante Jonathan C Choy

The nature of inflammatory signals determines the outcome of T cell responses. However, little is known about how inflammatory cytokines provided to human CD8 T cells during activation affects their susceptibility to post-activation cell death. We have examined and compared the effects of the inflammatory cytokine IL-12, as well as the combination of IL-1, IL-6, and IL-23 (IL-1/6/23) on the sus...

Journal: :Endocrine journal 2014
Rosaria Maddalena Ruggeri Salvatore Saitta Mariateresa Cristani Salvatore Giovinazzo Valeria Tigano Francesco Trimarchi Salvatore Benvenga Sebastiano Gangemi

Recent studies have demonstrated that T-helper 17 lymphocytes (Th17), which produce mostly IL-17, play a major role in several autoimmune diseases commonly thought to be Th1-related, including Hashimoto's thyroiditis (HT). IL-23, a member of the IL-12 cytokine family, is known to guide T cells toward the Th17 phenotype and its serum levels are increased in several autoimmune disease. Few data a...

2015
Julie Plée Sébastien Le Jan Jérôme Giustiniani Coralie Barbe Pascal Joly Christophe Bedane Pierre Vabres François Truchetet François Aubin Frank Antonicelli Philippe Bernard

Bullous pemphigoid (BP) is an inflammatory autoimmune bullous disease involving cytokines and proteases in the process of blister formation. Recently, IL-17 and IL-23 were evidenced in lesional skin and serum of BP patients at time of diagnosis, but their involvement in disease outcome has still not been investigated yet. We then analysed IL-17 and IL-23 serum levels during the first months of ...

Journal: :Journal of immunology 2013
Marylène Lecocq Bruno Detry Amélie Guisset Charles Pilette

We showed that IgA induces IL-10 in monocytes and dendritic cells. Because reciprocal inhibition exists between IL-10 and IL-12, we explored whether IgA could regulate this other immunoregulatory cytokine. In human monocytes and monocyte-derived dendritic cells preincubated with IFN-γ before stimulation by LPS, suppression of p40 and IL-12p70 production was observed upon IgA treatment during IF...

Journal: :Journal of immunology 2011
Jean-Marc Doisne Valérie Soulard Chantal Bécourt Latiffa Amniai Pauline Henrot Colin Havenar-Daughton Charlène Blanchet Laurence Zitvogel Bernhard Ryffel Jean-Marc Cavaillon Julien C Marie Isabelle Couillin Kamel Benlagha

We have shown previously that peripheral lymph node-resident retinoic acid receptor-related orphan receptor γt(+) NK1.1(-) invariant NKT (iNKT) cells produce IL-17A independently of IL-6. In this study, we show that the concomitant presence of IL-1 and IL-23 is crucial to induce a rapid and sustained IL-17A/F and IL-22 response by these cells that requires TCR-CD1d interaction and partly relies...

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