نتایج جستجو برای: interleukin 18

تعداد نتایج: 441803  

Journal: :Journal of immunology 2003
Tania Azam Daniela Novick Philip Bufler Do-Young Yoon Menachem Rubinstein Charles A Dinarello Soo Hyun Kim

Steady state mRNA levels in various human tissues reveal that the proinflammatory cytokine IL-18 is constitutively and ubiquitously expressed. However, limited IL-18R alpha-chain (IL-18Ralpha) expression in tissues may restrict ligand-acting sites and contribute to a specific response for IL-18. To study the IL-18R complex, [(125)I]IL-18 was studied for binding to the cell surface receptors of ...

Journal: :International Journal of Molecular Sciences 2019

Journal: :The European respiratory journal 1999
L A Cameron R A Taha A Tsicopoulos M Kurimoto R Olivenstein B Wallaert E M Minshall Q A Hamid

Interleukin (IL)-18 is an interferon (IFN)-gamma-inducing cytokine suggested to be important in regulating inflammatory responses. This study investigated the pulmonary expression of IL-18 under conditions characterized by T-helper (Th)1 (lipopolysaccharide (LPS) treatment/sarcoidosis) and Th2 (ovalbumin (OVA) challenge/asthma) cytokine production. In situ hybridization and immunocytochemistry ...

Journal: :Infection and immunity 2000
J K Brieland C Jackson S Hurst D Loebenberg T Muchamuel R Debets R Kastelein T Churakova J Abrams R Hare A O'Garra

The in vivo role of endogenous interleukin-18 (IL-18) in modulating gamma interferon (IFN-gamma)-mediated resolution of replicative Legionella pneumophila lung infection was assessed using a murine model of Legionnaires' disease. Intratracheal inoculation of A/J mice with virulent bacteria (10(6) L. pneumophila organisms per mouse) resulted in induction of IL-18 protein in bronchoalveolar lavag...

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