Abstract Hydroxysafflor yellow A is extracted from Carthamus tinctorius L., Asteraceae, and has extensive pharmacological properties. In this study, interleukin-1 beta was used to establish the osteoarthritis model in vitro , impacts of hydroxysafflor on cell were analyzed. CCK8 measure viability, flow cytometry evaluate apoptosis reactive oxygen species. An enzyme-linked immunosorbent assay pe...