Long-distance chromosomal interactions are emerging as a potential mechanism of gene expression control. In this issue, Apostolou and Thanos (2008) describe how viral infection elicits interchromosomal associations between the interferon-beta (IFN-beta) gene enhancer and DNA binding sites of the transcription factor NF-kappaB, resulting in the initiation of transcription and an antiviral response.

Then, using all of these tags were used to calculate intrachromosomal LD within each panel. Analysis was done using an EM algorithm based on code from Goncalo Abecasis. Marker pairs with r2 0.6 were stored for further analysis. As shown in Table 2, the number of distinct pairs of SNPs with r2 0.6 and 0.8 are shown. The numbers are shown for the original tag set. Additionally, to facilitate cros...

A new allele of the 27-kD zein locus in maize has been generated by interchromosomal recombination between chromosomes of two different inbred lines. A continuous patch of at least 11,817 bp of inbred W64A, containing the previously characterized Ra allele of the 27-kD zein gene, has been inserted into the genome of A188 by a single crossover. While both junction sequences are conserved, sequen...

LTHOUGH the properties of crossing-over have been investigated extenA sively in Drosophila melanogaster, the influence of nonhomologous chromosomes on crossing-over is a problem that warrants further exploration. Since STURTEVANT’S (1919) observation that a heterozygous inversion in the third chromosome increased crossing-over in chromosome 2, many investigators such as SCHULTZ and REDFIELD in ...

ETEROZYGOUS autosomal translocations have been shown to affect recomHbination in the X chromosome in various ways (HINTON 1965); translocations with long interstitial distances increased recombination in X, those with short interstitial distances decreased recombination in X, and those with intermediate interstitial distances had little or no effect. Other incidental tests of translocation hete...