In India, a significant percentage of high risk births, which go upto 20%, are affected by perinatal asphyxia. Birth asphyxia is associated with deficient mental and physical development, severity of which leads to mortality. It is very important that a comprehensive quantitative study of the phenomenon be undertaken and a risk index formulated. Preventive measures can then be fciken to avert t...

The aim of the investigation was to evaluate the diagnostic value of the study serum and urinary contents of γ-glutamyl transpeptidase (GGTP) in newborns with impaired renal function due to asphyxia. Materials and Methods. Investigation included 200 full-term newborns with disturbance kidney function: 100 infants who had severe asphyxia, and 100 — with moderate asphyxia. Comparison group consis...

Mammalian birth is accompanied by a period of obligatory asphyxia, which consists of hypoxia (drop in blood O2 levels) and hypercapnia (elevation of blood CO2 levels). Prolonged, complicated birth can extend the asphyxic period, leading to a pathophysiological situation, and in humans, to the diagnosis of clinical birth asphyxia, the main cause of hypoxic-ischemic encephalopathy (HIE). The neur...

BACKGROUND Perinatal asphyxia is a major cause of neurologic morbidity and mortality. The purpose of this study was to investigate variations in nucleated red blood cell (NRBC) count per 100 white blood cells (WBC) and absolute NRBC/mm3 in blood associated with perinatal asphyxia and its relationship to both the severity and short term prognosis of asphyxia. METHODS A prospective (case-contro...

OBJECTIVE To assess the annual burden of early neonatal deaths associated with perinatal asphyxia in infants weighing ≥2500g in Brazil from 2005 to 2010. METHODS The population study enrolled all live births of infants with birth weight ≥2500g and without malformations who died up to six days after birth with perinatal asphyxia, defined as intrauterine hypoxia, asphyxia at birth, or meconium ...

OBJECTIVE To describe possible causes of delivery-related severe asphyxia due to malpractice. DESIGN AND SETTING A nationwide descriptive study in Sweden. POPULATION All women asking for financial compensation because of suspected medical malpractice in connection with childbirth during 1990-2005. METHOD We included infants with a gestational age of >or=33 completed gestational weeks, a p...

Positional asphyxia, a fatal condition arising because of the adoption of particular body positions, causing mechanical interference with pulmonary ventilation, can occur in various circumstances that are likely to come under the observation of the specialist in legal medicine (work, car accidents, torture, kidnapping, etc.). It is difficult to diagnose the cause of death in such cases because ...

OBJECTIVE Vitamin D deficiency causes not only skeletal problems but also muscle weakness, including heart muscle. If the fetal heart is also affected, it might be more susceptible to fetal distress and birth asphyxia. In this pilot study, we hypothesised that low maternal vitamin D levels are over-represented in pregnancies with fetal distress/birth asphyxia. DESIGN AND SETTING A population-...

Cooling is known to prolong survival in newborn animals when used before the onset of asphyxia. It has therefore been advocated as a treatment for birth asphyxia in humans. Since it is not possible to cool a human baby before the onset of birth asphyxia, experiments were designed to test the effect of cooling after asphyxia had already started. Newborn rabbits were asphyxiated in 100% nitrogen ...

BACKGROUND A proportion of neonatal deaths from asphyxia have been shown to be associated with pre-existing brain injury. OBJECTIVES (a) To compare the epidemiology of infants displaying signs of birth asphyxia with those not showing signs; (b) to examine the neuropathology and determine if possible the timing of brain insult comparing asphyxiated with non-asphyxiated infants; (c) to compare ...