Introduction: Human embryonic stem cells (hESCs) are pluripotent cells that can proliferate and differentiate to many cell types. Their electrophysiological properties have not yet been chracterzed. In this study, the passive properties (such as resting membrane potential, input resistance and capacitance) and the contribution of delayed rectifier K+ channel currents to the membrane conducta...

in the middle ages, there are many intellectual currents in judaism.a current of thought is in disagreement with the philosophy. some have criticized philosophers from theological perspective and grups have criticized philosophy with the help of fallcy and its own philosophy.in this regard.helevy has a privileged position.he emphasized on the limits of reason and insufficient in explaining the ...

competition is against monopoly and intellectual property creates monopoly for intellectual property owner. this article had been paid cooperation between apparently contradictory policies. exhaustion, parallel imports, compulsory license, intellectual property exploitation contract that coincide with competition are methods of cooperation between intellectual property and competition law. comp...

submerged breakwaters are one of the shore protective structures. any discontinuity in these breakwaters causes changes on current parameters including speed and water surface profile. in this paper, discontinuous submerged breakwaters were modelled to investigate the changes in the wave and flow pattern.to investigate the phenomenon, three models including a shore with constant slope, a shore ...

The goal of this study was to determine the effects of the L-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fKv1.4ΔN), an N-terminal-deleted mutant of the ferret Kv1.4 potassium channel. Measurements were made using a two electrode voltage clamp technique with channels expressed stably in Xenopus oocytes. The fKv1.4ΔN currents displayed...

In recent years, supporting intellectual property right has gained more significance. Intellectual property rights could be considered as legal rights resulting from intellectual activities in industrial, scientific, literary and artistic fields. Today, many countries are seeking practical information about using intellectual property to improve economic growth. Intellectual property rights hav...

ion channels are responsible for control of cell function in excitable tissues such as heart and brain and also in organs and tissues traditionally thought to be non- excitable including liver and epithelium. in the present research, the effect of lead (pb2+) on ca2+ -dependent action potential and currents was studied in f77 neuronal soma membrane of helix aspersa. for this purpose, action pot...

OBJECTIVE To determine the functional effect of SCN8A missense mutations in 2 children with intellectual disability and developmental delay but no seizures. METHODS Genomic DNA was analyzed by next-generation sequencing. SCN8A variants were introduced into the Nav1.6 complementary DNA by site-directed mutagenesis. Channel activity was measured electrophysiologically in transfected ND7/23 cell...