PURPOSE Precocious puberty has significantly increased recently. While obesity is associated with puberty timing, the relationship between obesity and central precocious puberty (CPP) remains controversial. The purpose of this study was to determine whether insulin resistance is associated with bone age (BA) advancement in girls with CPP. METHODS We retrospectively analyzed the records of 804...

OBJECTIVE Recently, it has been questioned whether insulin resistance is associated with thyroid nodules. The aim of this study was to examine insulin resistance prevalence in a case-control study of patients with benign thyroid nodules in an iodine-sufficient area. METHODS This was a single-center, case-control study on euthyroid patients with benign nodular diseases. Thirty newly diagnosed ...

Science is still searching for readily available, cost-effective biomarkers to assess metabolic disorders occurring before the onset and during development of type-2 diabetes (T2DM). The aim present study was induce T2DM in rats through a high-fat diet, followed by single administration low dose streptozotocin (STZ), make an assessment disease. were divided into two groups—experimental control—...

BACKGROUND The insulin resistance syndrome is one of the major contributors of metabolic syndrome, diabetes Type 2 and atherosclerotic cardiovascular disease. A common mutation (677C to T; Ala to Val) in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with decreased specific MTHFR activity and elevation of the homocysteine. The aim of this study is investigation of associatio...

OBJECTIVE To identify cutoff points of the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index established for adolescents and discuss their applicability for the diagnosis of insulin resistance in Brazilian adolescents. DATA SOURCE A systematic review was performed in the PubMed, Lilacs and SciELO databases, using the following descriptors: "Adolescents", "insulin resistance"...

BACKGROUND AND OBJECTIVES Insulin resistance has been associated with cardiovascular disease in peritoneal dialysis patients. Few studies have addressed the impact of fast transport status or dialysis prescription on insulin resistance. The aim of this study was to test whether insulin resistance is associated with obesity parameters, peritoneal transport rate, and glucose absorption. DESIGN,...

the aim of this study was to determine the effect of resistance training for 10 weeks on muscle strength, lean body mass, serum myostatin, and insulin resistance in obese-overweight men. seventeen obsess-overweight men(age:=43.1±4.7 yr, body mass index = 29.1±2.17 kg/m2) participated in the study the subjects were randomly assigned to resistance training (n=9) and control (n=8) groups. resistan...

Epidemiological studies have implicated obstructive sleep apnea (OSA) as an independent comorbid factor in cardiovascular and cerebrovascular diseases. It is postulated that recurrent episodes of occlusion of upper airways during sleep result in pathophysiological changes that may predispose to vascular diseases. Insulin resistance is a known risk factor for atherosclerosis, and we postulate th...

Although moderate drinking has been shown to lower insulin resistance levels, it is still unclear whether alcoholic beverages could be remedies for insulin resistance. To elucidate this, the correlation between levels of ethanol consumption and insulin resistance were cross-sectionally examined in 371 non-diabetic male Japanese workers. Multiple regression analysis demonstrated that the ethanol...

BACKGROUND Several epidemiologic studies showed the significant association of insulin resistance with asthma. OBJECTIVE The aim of this study was to evaluate the association of insulin resistance with airway hyperresponsiveness (AHR) in adult population. METHODS 1,058 subjects who visited to the Seoul National University Hospital Gangnam Center from October 2007 to January 2009 for a routi...