Inactivating mutations of the SOST (sclerostin) gene are associated with overgrowth and sclerosis of the skeleton. To determine mechanisms by which increased amounts of calcium and phosphorus are accreted to enable enhanced bone mineralization in the absence of sclerostin, we measured concentrations of calciotropic and phosphaturic hormones, and urine and serum calcium and inorganic phosphorus ...

The basic aspects of bone tissue engineering include chemical composition and geometry of the scaffold design, because it is very important to improve not only cell attachment and growth but especially osteodifferentiation, bone tissue formation, and vascularization. Geistlich Bio-Oss (GBO) is a xenograft consisting of deproteinized, sterilized bovine bone, chemically and physically identical t...

The aim of this study was to evaluate the regeneration bone defects created in femoral condyle osteoporotic rats, following intravenous (IV) zoledronate (ZA) treatment three settings: pre-bone grafting (ZA-Pre), post-bone (ZA-Post), and pre- plus (ZA-Pre+Post). Twenty-four female Wistar rats were ovariectomized (OVX). After 12 weeks, left condyle. All grafted with a particulate inorganic cancel...

Our aim was to compare the osteogenic potential of mononuclear cells harvested from the iliac crest combined with bovine bone mineral (BBM) (experimental group) with that of autogenous cancellous bone alone (control group). We studied bilateral augmentations of the sinus floor in 6 adult sheep. BBM and mononuclear cells (MNC) were mixed and placed into one side and autogenous bone in the other ...

Biomaterials containing components similar to the native biological tissue would have benefits as an implantable scaffold material. To obtain such biomimetic materials, cells may be great contributors because of their crucial roles in synthetic organics. In addition, the synthesized organics-especially those derived from osteogenic differentiated cells-become a place where mineral crystals nucl...

Human bone is a complex hierarchical material. Understanding bone structure and its corresponding composition at the nanometer scale is critical for elucidating mechanisms of biomineralization under healthy and pathological states. However, the three-dimensional structure and chemical nature of bone remains largely unexplored at the nanometer scale due to the challenges associated with characte...

purpose: given that weight and body mass index (bmi) are considered as modifiable factors in osteoporosis, the present study aimed to examine the relationship of weight and bmi with bone mineral density (bmd) and bone mineral content (bmc) at the femur and lumbar vertebrae in perimenopausal women. methods: in this descriptive-correlational study, we measured the bone density of the femur and lu...

Carbonate-substituted hydroxylapatite is the inorganic component in bone. The nanometer size of bone crystallites and their interweaving with subequal volumes of collagen fibrils make the chemical analysis of the bone mineral extremely difficult. The few chemical analyses that are available commonly were made on ashed bone, which, in addition to mineral, also includes chemical residues of colla...

Lack of cytocompatibility in bone substitutes impairs healing in surrounding bone. Adverse biological events around biomaterials may be associated with oxidative stress. We hypothesized that a clinically used inorganic bone substitute is cytotoxic to osteoblasts due to oxidative stress and that N-acetyl cysteine (NAC), an antioxidant amino acid derivative, would detoxify such material. Only 20%...

background: fluoride (f−) is a trace element that is incorporated into bone mineral during bone formation. this study assessed the effect of increasing fluoride doses on the bone formation and microarchitecture on the femur of rats by histological, and histometrical methods. materials and methods: a total of 16 rats was divided into one group of control and three groups of animals that received...