objective(s): chemoresistance remains the main causes of treatment failure and mortality in cancer patients. there is an urgent need to investigate novel approaches to improve current therapeutic modalities and increase cancer patients' survival. induction of drug efflux due to overexpression of                  p-glycoproteins is considered as an important leading cause of multidrug resis...

Although TGF-β is known to be related tumor proliferation, invasion and epithelial-mesenchymal transition (EMT), its effects on oral carcinomas remain unclear. This study aimed elucidate the of squamous cell carcinoma (OSCC). In present in vitro study, three human OSCC lines; SAS (tongue cancer), Ca9-22 (mandibular gingival cancer) HSC-3 (cervical lymph nodes metastasis tongue were treated with...

background micrornas are small and non-coding rna molecules with approximately 22 nt in length that cause inhibition of translation or degradation of mrna. mir-155 is a kind of molecule with different functions, such as its role in proliferation, apoptosis, inflammation, differentiation, and immunity. one of its best known functions is apoptosis that affects on caspase-3 activity. the main aim ...

Abstract PD1/PDL1 interactions exert potent inhibitory effects on T cell responses. Inhibition of this pathway results in greater responses and is increasingly used cancer immunotherapy but the long-term PD1 inhibition activation remain unclear. We hypothesized that these gains proliferation cells over time may result loss due to apoptosis via induced death (AICD). investigated using both mouse...

development of phytotherapies aimed at angiogenesis inhibition, in combination with classical anti-cancer therapies, is among the most intensively studied approaches for treatment of cancer. epidemiological and animal studies have indicated that consumption of allium species like shallot is associated with a reduced risk of cancer development. as a continuation of our efforts to study and chara...

The precise role of the microenvironment on tumor growth is poorly understood. Whereas the tumor is in constant competition with the surrounding tissue, little is known about the mechanics of this interaction. Using a novel experimental procedure, we study quantitatively the effect of an applied mechanical stress on the long-term growth of a spheroid cell aggregate. We observe that a stress of ...

Introduction: Nogo-A and Nogo receptor (NgR) are expressed in the subventricular zone (SVZ) stem cells. NgR plays critical inhibitory roles in axonal regeneration and remyelination. However, the role of NgR in SVZ niche behaviors in demyelination context is still uncertain. Here we investigated the effects of NgR inhibition on SVZ niche reaction in a local model of demyelination in adult mouse ...

silybum marianum, is known to have anti-inflammatory, hepatoprotective and anticarciogenic effects. the aim of this study was to compare effects of silymarin, rapamycin and fk506 on proliferation and apoptosis of human t cells stimulated with con a. peripheral blood mononuclear cells (pbmc) were stimulated with concavalin a  ( con a) (5µg/ml) and then treated with different inhibitors (silymari...

introduction: accumulating evidences indicated that during increasing of the animals' age, the number and the functional properties of hematopoietic stem cells (hscs) become altered because of a gradual decrease in replication potential.  the efficient factors in this process are dna damaging, reduced telomerase activity, shortening of telomeres and oxidative stresses. for overcoming these fact...

nucleostemin (ns), a stem cell-abundant nucleolar protein, is critical for maintaining the self-renewal and proliferative properties of normal and cancerous stem cells. recent data suggests that ns signaling is important for proliferation of t-cells and leukemia cells. this study was conducted to verify the role of ns in pathogenesis and treatment of t-cell acute lymphocytic leukemia (t-all). o...