Journal:
:iranian journal of virology
0
m ghaderi national influenza center, school of public health, tehran university of medical sciences, tehran, iran
t mokhtari-azad national influenza center, school of public health, tehran university of medical sciences, tehran, iran
sh shahmahmoodi national influenza center, school of public health, tehran university of medical sciences, tehran, iran
k samimi-rad national influenza center, school of public health, tehran university of medical sciences, tehran, iran
j yavarian national influenza center, school of public health, tehran university of medical sciences, tehran, irannational influenza center, school of public health, tehran university of medical sciences, tehran, iran
m naseri national influenza center, school of public health, tehran university of medical sciences, tehran, irannational influenza center, school of public health, tehran university of medical sciences, tehran, iran
background and aims: influenza a viruses are important pathogens for humans especially in pandemic episodes. two adamantane derivates, amantadine and rimantadine, are used for prophylaxis and treatment of influenza a virus infections. however, single amino acid substitutions in the m2 transmembrane domain which lead to amantadine resistance of these viruses occur at residues 26, 27, 30, 31 or 3...