Introduction: Brain injury induces an almost immediate response from glial cells, especially astrocytes. Activation of astrocytes leads to the production of inflammatory cytokines and reactive oxygen species that may result in secondary neuronal damage. Melatonin is an anti-inflammatory and antioxidant agent, and it has been reported to exert neuroprotection through the prevention of neuronal d...

Background: Interleukin 6 (IL-6) functions as both a pro-inflammatory cytokine and an anti-inflammatory cytokine. Objective: To evaluate the levels of IL-6 in patients with multiple organ dysfunction syndrome (MODS). Methods: Level of IL-6 was assessed and recorded for 14 days subsequent to the injury in 161 multiple trauma patients. MODS were diagnosed using Marshal Score. Injury Severity Scor...

An immediate consequence of traumatic brain injury (TBI) is the induction of an inflammatory response. Mounting data suggest that inflammation is a major contributor to TBI-induced brain damage. However, much remains unknown regarding the induction and regulation of the inflammatory response to TBI. In this study we compared the TBI-induced inflammatory response to severe parenchymal injury (co...

Background: Acute lung injury (ALI) is among the most serious conditions characterized by an exacerbation of inflammatory response that can result from a persistent infection. Carvone chiral monoterpenoid ketone present in essential oils dill, caraway, and spearmint. It shows antioxidant, anti-inflammatory, antimicrobial effects others. In this study, anti-inflammatory protective potential mech...

Bacterial endotoxin has been known to induce excessive inflammatory responses and acute kidney injury. In the present study, we used a mouse model of endotoxemia to investigate the role of Sirt1 in inflammatory kidney injury. We examined molecular and cellular responses in inducible Sirt1 knockout (Sirt1-/-) mice and wild type littermates (Sirt1+/+) in lipopolysaccharide (LPS)-induced kidney in...

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with excess mortality worldwide. The cardiovascular system is second most common target of SARS-CoV-2, which leads to complications, including myocardial injury, myocarditis, arrhythmias, and venous thromboembolism, as well other major thrombotic events because dire...

conclusions il-33 may be a potential new agent to attenuate rir injury by reducing inflammatory cell infiltration and preventing apoptosis. results our data revealed that il-33 pretreatment maintained a better retinal structure, inhibited leukocyte infiltration (il-33 vs. mg with p < 0.01 and il-33 vs. pbs group with p < 0.01), and reduced the apoptosis of retinal ganglion cells (il-33 vs. mg w...

Epidemiological studies suggest that acute kidney injury has certain effect on myocardial function. In this study, for the first time, we tested a boron compound namely lithium tetraborate an act as anti-oxidant and anti-inflammatory agent in ischemia-reperfusion injury. For this, employed vivo rat model with ischemia reperfusion to evaluate cardiac clarify mechanisms of tetraborate. The evalua...

Purpose: To investigate the biological functions of miR-423-5p in a mouse model with lipopolysaccharide (LPS)-induced acute liver injury.Methods: Sixty male C57BL/6 mice were randomized into control group (n = 20), LPS 20) and + mimic 20). The levels pro-inflammatory cytokines apoptosisassociated proteins tissues determined. Finally, survival was recorded within 7 days after injection LPS.Resul...