Due to impaired defensive mechanisms caused by injuries or little epithelial defects , different types of pathogens or environmental influences might induce corneal inflammation (keratitis). The form of corneal inflammation called superficial keratitis involves just the corneal surface (epithelium). If the inflammation involves corneal stroma it is called stromal or interstitial keratitis. Kera...

PURPOSE To report the use of corneal collagen crosslinking in the treatment of infective keratitis not responding to antimicrobial therapy. METHODS Two retrospective case reports of infective keratitis treated with corneal collagen crosslinking. RESULTS In both cases, corneal collagen crosslinking caused a rapid resolution of the infective keratitis, leaving residual stromal scarring. Due t...

1)Methods section did not have enough detailed information about the recruitment of patients and the examinations Response: Thanks for the reviewer’s kind suggestion.According to his/her advices, the manuscript has been modified,page 2, Methods section 2) Is the conclusion really reflecting the actual conclusion of the study? Response: Thanks for the reviewer’s suggestion.The manuscript has bee...

PURPOSE To evaluate the efficacy of ultraviolet-corneal cross-linking (CXL) for treating infectious melting keratitis. METHODS Five patients with infectious keratitis associated with corneal melting were treated with CXL at the outpatient departments of the Institut für Refraktive und Ophthalmo-Chirurgie and the eye hospital at the University of Zurich. CXL was performed when the infection di...

To investigate the incidence, culture results, treatment, and visual outcomes of infectious keratitis after laser in situ keratomileusis (LASIK) worldwide, the Cornea Clinical Committee of the American Society of Cataract and Refractive Surgery (ASCRS) contacted 8600 United States and international ASCRS members by e-mail and asked them to respond to a questionnaire about post-LASIK infectious ...

Bacterial keratitis is a sight-threatening corneal disease that is most commonly associated with the extended wear of soft contact lenses. Over the past decade, we have investigated the pathogenesis of infectious keratitis involving the opportunistic pathogen Pseudomonas aeruginosa. Our research has focused on understanding the respective roles of bacteria and host in the establishment of this ...

PURPOSE To report a case of infectious keratitis after small incision lenticule extraction (SMILE) treated with collagen cross-linking with photoactivated riboflavin (PACK-CXL). METHODS Case report and literature review. RESULTS A patient presented with culture-proven bacterial keratitis 5 days after SMILE was treated with fortified topical antibiotics and PACK-CXL. Irrigation of the cornea...

PURPOSE To determine risk factors and clinical signs that may differentiate between bacterial, fungal, and acanthamoeba keratitis among patients presenting with presumed infectious keratitis. DESIGN Hospital-based cross-sectional study. METHODS We examined the medical records of 115 patients with laboratory-proven bacterial keratitis, 115 patients with laboratory-proven fungal keratitis, an...

AIM To study the indications of penetrating keratoplasty in Southern India. SETTINGS AND DESIGN Retrospective study. MATERIAL AND METHODS Retrospective evaluation of eye bank records from December, 2002 to December, 2012 with respect to indications for penetrating keratoplasty. RESULTS During the period considered for study, 102 penetrating keratoplasties were performed. The leading indic...

PURPOSE The aim of this study was to use Raman spectra of tears to differentiate between infectious and noninfectious ulcerative keratitis. METHODS Raman microspectroscopy was applied using the drop-coating deposition method on Ti/Au-coated glass slides to obtain sample spectra from different human tear groups, including tears from healthy subjects and from patients with infectious and noninf...