UNLABELLED In vitro, infection of polarized human intestinal epithelial cells by coxsackievirus B3 (CVB3) depends on virus interaction with decay-accelerating factor (DAF), a receptor expressed on the apical cell surface. Although mice are highly susceptible to CVB3 infection when virus is delivered by intraperitoneal injection, infection by the enteral route is very inefficient. Murine DAF, un...

Biliary liver flukes are common parasites in some regions of the world where consumption of raw fresh-water fish is a cultural practice. Clonorchis sinensis and Opisthorchis species are the major biliary liver flukes associated with human disease. Some of these parasites are highly associated with cholan...

REFERENCES A photograph of third-stage (L3) Anisakis simplex larvae in the gastric cavity of BALB/c mice is provided here. Anisakis nematodes (Figure A; arrows) are white and cylindrical and measure approximately 2 to 3 centimeters in length. Human anisakiasis, an emerging disease often triggered by eating fi sh infected with Anisakis sp., is not widely studied in Latin America. Mouse models ha...

In Nova Scotia the main manifestation of acute Q fever is pneumonia, while in France it is granulomatous hepatitis. To test the hypothesis that the route of infection is the major determinant of the manifestations of acute Q fever, 10 groups of 10- to 12-g female BALB/c mice (4 animals/group) were used. Five groups were inoculated intraperitoneally (ip) and 5 intranasally (inl) with Coxiella bu...

Mucosal and parenteral immunizations elicit qualitatively distinct immune responses, and there is evidence that mucosal immunization can skew the balance of T helper 1 and T helper 2 responses. However, a clear picture of the effect of the route of infection on the balance of the T helper responses has not yet emerged. Our laboratory previously demonstrated that oral reovirus infection elicits ...

biliary liver flukes are common parasites in some regions of the world where consumption of raw fresh-water fish is a cultural practice. clonorchis sinensis and opisthorchis species are the major biliary liver flukes associated with human disease. some of these parasites are highly associated with cholangiocarcinoma. this report describes a clinically and epidemiologically unsuspected liver flu...

over 170 million patients worldwide are chronically infected with hepatitis c virus ( hcv ); making it a globally important infection. dentists constantly handle sharp instruments infected with biological fluids and are therefore considered at high-risk of contracting hcv infection. needle-stick injuries seem to be the most common route of exposure to blood-borne pathogens in dental practice. m...

Leishmania tropica is one of the causative agents of leishmaniasis in humans. Routes of infection have been reported to be an important variable for some species of Leishmania parasites. The role of this variable is not clear for L. tropica infection. The aim of this study was to explore the effects of route of L. tropica infection on the disease outcome and immunologic parameters in BALB/c mic...