BACKGROUND Infarct size is a strong predictor of mortality and major adverse cardiovascular events after myocardial infarction. Acute reperfusion therapy limits infarct size and improves survival, but its use has been confined to patients with ST-segment-elevation myocardial infarction. The purpose of this study was to assess the relationship between echocardiographic parameters of left ventric...

effects of doxycycline on cx43 distribution and cardiac arrhythmia susceptibility of rats after myocardial infarction abstract: this study aimed to observe the effects of doxycycline (dox) on gap junction remodeling after mi and the susceptibility of rats to cardiac arrhythmia. the proximal left anterior descending coronary artery of rats was ligated to establish a myocardial infarction animal ...

BACKGROUND Bao-Xin-Tang (BXT) is a traditional Chinese medicinal formula used for the treatment of coronary heart disease and known to have favorable therapeutic benefits. The current study was designed to determine whether BXT has a cardioprotective role for acute myocardial infarction. The underlying mechanisms were also explored. MATERIALS AND METHODS The Sprague-Dawley rat model of acute ...

OBJECTIVES The aim of this research was to test whether constitutive expression of hypoxia-inducible factor 1-alpha (HIF-1alpha) influences infarction size and cardiac performance after myocardial infarction. BACKGROUND A major question in clinical medicine is whether infarction size and border zone remodeling of the heart can be influenced by the overexpression of specific genes in the peri-...

OBJECTIVE To investigate whether transient ischemic attack (TIA) had an ischemic preconditioning neuroprotective effect on subsequent cerebral infarction. PATIENTS AND METHODS 232 patients with cerebral infarction were selected and divided into Group A (<55 years old), Group B (55-75 years old) and Group C (>75 years old), according to age. Each group was further divided into sub-groups A1, A...

We prospectively investigated whether 20'TI single-photon emission computed tomography (SPECT) could accurately diagnose the presence and quantify the extent of acute myocardial infarction when compared with infarct size assessed by plasma MB-creatine kinase activity. Thirty patients with enzymatic evidence of infarction were imaged within 12-36 hours of chest pain (mean, 23.4 hours). No patien...

BACKGROUND Lacunar infarctions are caused by small vessel disease (SVD) and branch atheromatous disease (BAD). Lacunar infarction may be classified as proximal vessel lacunar infarction (BAD) or distal vessel lacunar infarction (SVD) according to its location within the middle cerebral artery (MCA) territory in patients with normal MCA. Studies found that the lenticulostriate arteries may exist...

BACKGROUND To explore the pathological changes of three-dimension structure of ventricular myocardial fibers after anterior myocardial infarction in dog heart. METHODS Fourteen acute anterior myocardial infarction models were made from healthy dogs (mean weight 17.6 ± 2.5 kg). Six out of 14 dogs with old myocardial infarction were sacrificed, and their hearts were harvested after they survive...