نتایج جستجو برای: induced tracheal damage

تعداد نتایج: 1163749  

Journal: :The Journal of pharmacology and experimental therapeutics 2002
Sandie Escotte Claire Danel Dominique Gaillard Sylvie Benoit Jacky Jacquot Daniel Dusser Jean-Michel Triglia Caroline Majer-Teboul Edith Puchelle

Airway inflammation, one of the major factors leading to lung damage in cystic fibrosis (CF) patients, is associated with an abnormal increase in proinflammatory cytokines. In this work, we demonstrate the increased release of the proinflammatory cytokines after lipopolysaccharide (LPS) stimulation: human interleukin (hIL)-8 in CF and non-CF airway xenografts, and hIL-6 and human growth-related...

Inhalational insulin was withdrawn from the market due to its potential to produce airway hyper-reactivity and bronchoconstriction. So the present study was designed to explore the acute effects of insulin on airway reactivity of guinea pigs and protective effects of salbutamol and beclomethasone against insulin induced airway hyper-responsiveness on isolated tracheal smooth muscle of guinea pi...

Inhalational insulin was withdrawn from the market due to its potential to produce airway hyper-reactivity and bronchoconstriction. So the present study was designed to explore the acute effects of insulin on airway reactivity of guinea pigs and protective effects of salbutamol and ipratropium against insulin induced airway hyper-responsiveness on isolated tracheal smooth muscle of guinea pig. ...

Journal: :The European respiratory journal 1996
U M Wells Z Hanafi J G Widdicombe

Inhaled sodium metabisulphite (MBS) causes bronchoconstriction, cough and microvascular leakage. We have studied its effects on tracheal blood flow, potential difference (PD) and the permeability from tracheal lumen to venous blood of a low molecular weight hydrophilic tracer, 99mtechnetium-labelled diethylenetriamine penta-acetic acid (99mTc-DTPA) in anaesthetized sheep. Flow was measured in t...

Journal: :iranian journal of pharmaceutical sciences 0
mahjabeen sharif assistant professor army medical college rawalpindi bushra tayyaba khan army medical college mubashir sharif afid rawalpindi afsheen sharif department of pharmaceutical sciences, riphah institute of pharmaceutical sciences islamabad, pakistan.

inhalational insulin was withdrawn from the market due to its potential to produce airway hyper-reactivity and bronchoconstriction. so the present study was designed to explore the acute effects of insulin on airway reactivity of guinea pigs and protective effects of salbutamol and ipratropium against insulin induced airway hyper-responsiveness on isolated tracheal smooth muscle of guinea pig. ...

2005
Sunanda Gupta Rajesh Sharma

Respiratory events are the most common anaesthetic related injuries, following dental damage. The three main causes of respiratory related injuries are inadequate ventilation, oesophageal intubation and difficult tracheal intubation. Difficult tracheal intubation accounts for 17% of the respiratory related injuries and results in significant morbidity and mortality. In fact up to 28% of all ana...

Journal: :American journal of respiratory cell and molecular biology 2003
Mizue Nakajoh Takeyasu Fukushima Tomoko Suzuki Mutsuo Yamaya Katsutoshi Nakayama Kiyohisa Sekizawa Hidetada Sasaki

The protective effects of retinoic acid on elastase-induced lung epithelial cell injury were studied using elastase extracted from purulent human sputum, the BEAS-2B human bronchial epithelial cell line, A549 human type II lung cell line, and primary cultures of human tracheal epithelial cells. Elastase decreased viability of BEAS-2B cells, A549 cells, and human tracheal epithelial cells in con...

2010
Jyi Lin Wong Siew Teck Tie Bohari Samril Chee Lun Lum Mohammad Rizal Abdul Rahman Jamalul Azizi Abdul Rahman

Tracheal stenosis is a known complication of prolonged intubation. It is difficult to treat and traditional surgical approach is associated with significant risk and complications. Recurrent stenosis due to granulation tissue necessitates repeated procedures. We describe a case of short web-like tracheal stenosis (concentric membranous stenosis less than 1 cm in length without associated cartil...

2002
Z.-X. WU B. E. SATTERFIELD J. S. FEDAN Robert C. Byrd

Wu, Z.-X., B. E. Satterfield, J. S. Fedan, and R. D. Dey. Interleukin-1 -induced airway hyperresponsiveness enhances substance P in intrinsic neurons of ferret airway. Am J Physiol Lung Cell Mol Physiol 283: L909–L917, 2002. First published April 12, 2002; 10.1152/ajplung.00363.2001.—Interleukin (IL)-1 causes airway inflammation, enhances airway smooth muscle responsiveness, and alters neurotra...

2017
Carlos A Puyo Daniela Peruzzi Alexander Earhart Evan Roller Menelaos Karanikolas Marin H Kollef Alexander S Krupnick Daniel Kreisel Mohsen Ibrahim Andrew E Gelman

In the absence of infection, the pathophysiology of endotracheal tube-induced sore throat pain is unclear. Activated neutrophils release elastase, reactive oxygen species, and inflammatory cytokines known to contribute to neuropathic pain. Sterile tissue injury can cause the release of damage-associated molecular patterns such as mitochondrial DNA that promote neutrophil activation. We hypothes...

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