effects of insulin (1, 2 and 3 iu/kg, i.p.), morphine (5mg/kg, i.p.), naloxone (5mg/kg, s.c.), insulin before morphine and after naloxone were studied in the formalin test of mice. formalin test was induced by intraplantar injection of formalin (20m, 5%). morphine alone and insulin with morphine decreased the first phase (0-5 min) of pain. naloxone increased the interphase (6-20 min) of nicicep...

background: acupuncture is an indispensable part of traditional chinese medicine for relief of pain. the purpose of this study was the immediate & latent of low power laser ga-al-as irradiation applied to acupuncture points on experimental pain threshold. methods: this quasi-experimental study was conducted on seventy adult women ranging from 20 to 40 years old assigned randomly into two groups...

in the present study, the effects of the acute and chronic oral administrations (po) of curcumin in the absence and presence of morphine and naloxone was investigated on the sensation of acute corneal pain in rats. acute corneal pain was induced by the local application of hypertonic saline (5 m nacl) on the corneal surface, and the number of eye wipes was then counted for 30 s. subcutaneous (s...

introduction: 17β-estradiol modulates nociception by binding to estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and gabaa receptors. beside its autonomic functions, paragigantocellularis lateralis (lpgi) nucleus is also involved in pain modulation. the aim of the current study was to investigate the role of the intracellular estrogenic ...

inflammation and pain induced by delayed onset muscle soreness (doms) can be induced by eccentric exercise or an unaccustomed activity. the condition can causes problems in exercising and for athletes. the purpose of this study was to assess the effect of 150mg curcumin supplementation immediately after intensive eccentric exercise. evaluations were made for total antioxidant capacity (tac), mu...

background: ghrelin is a peptide with attenuating effect on inflammatory pain. both anti- and pro-inflammatory mediators have a role in the nociception and development of pain and hyperalgesia. il-10 and tgf-β are anti-inflammatory cytokines and inhibit the expression of pro-inflammatory cytokines related to peripheral and central inflammatory pain. in this study, the effects of i.p. injection ...

background & aim:zea mays leaf used traditionally in ibibio ethno medicine in southern nigeria to treat malaria and other inflammatory diseases. these anti-inflammatory and analgesic properties were evaluated against experimentally induced inflammation and pains using standard models. experimental: the effects of ethanol leaf extract of zea mays (170 -510 mg/kg) on experimentally induced inflam...