European Journal of Pharmaceutical Sciences 13 2001 123133 www.elsevier.nllocateejps. Modeling and comparison of dissolution profiles.To compare dissolution profiles between two drug products model dependent curve fitting, statistic analysis and model independent methods can be used. To compare dissolution profiles between two drug products model dependent curve fitting, statistic analysis and ...

This study presents improvement in solubility and dissolution rate of valsartan (VAL) using β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HP-βCD). Formation and characterization of solid inclusion complexes were investigated by DSC, FTIR, SEM, HNMR and in-vitro dissolution studies. Preparation method influenced physical properties of binary mixtures. Inclusion complexes obtained by co-...

      The in vitro dissolution of plasma-sprayed hydroxyapatite (PHA) coatings with different characteristics, produced by various spraying conditions, in a Tris-buffered solution at pH 7.4 was experimentally studied through the measurement of calcium ions release with Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES), and then modeled. Three coating characteristics, th...

The orally disintegrating tablet (ODT) is a novel dosage form that disintegrates in the oral cavity using saliva as the disintegrating medium and is swallowed as a fine dispersion. Due to rapid disintegration, the dissolution rate is controlled by the intrinsic solubility of the API; therefore, it is difficult to evaluate the effect of formulation and processing parameters on in vitro drug rele...

piroxicam, an anti-inflammatory drug, exhibits poor water solubility and flow properties, poor dissolution and poor wetting. consequently, the aim of this study was to improve the dissolution of piroxicam. microparticles containing piroxicam were produced by spray drying, using isopropyl alcohol and water in the ratio of 40:60 v/v as solvent system, and spray chilling technology by melting the ...

a study was conducted to investigate the effect of follicular size (small,

This paper presents results of a pharmacokinetics study concerning pentoxifylline and its main metabolites after administration of extended release formulation of Trental 400 mg and correlation of this pharmacokinetics with in vitro dissolution test results of parent drug. In order to establish most relevant in vitro test, dissolution was performed in different experimental conditions (stirring...

Poorly water-soluble drugs often suffer from limited or irreproducible clinical response due to their low solubility and dissolution rate. In this study, organic solvent-free solid dispersions (OSF-SDs) containing telmisartan (TEL) were prepared using polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 6000 (PEG 6000) as hydrophilic polymers, sodium hydroxide (NaOH) as an alkalizer, and ...

  Objective(s): The aim of this work was to investigate the effect of the natural and the chemically modified form of cyclodextrins namely; β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) respectively on the solubility and dissolution rate of aripiprazole; an antipsychotic medication showing poor aqueous solubility.   Materials and Methods: Phase solubility of ar...