human cytomegalovirus is one of the most common pathogenic viruses all over the world. in congenital infection leads to neurologic severe disorders and even death of fetus and in individuals with immunosuppression may also cause severe clinical symptoms. multiple evidence indicate that among several strategies, epitope-based vaccine (evs) that can induce both humoral and cellular immunity respo...

the properties relevant to pharmacokinetics and pharmacodynamics of four series of synthesized s-triazine derivatives have been studied by quantitative structure-retention relationship (qsrr) approach. the chromatographic behavior of these compounds was investigated by using reversed-phase high performance thin-layer chromatography (rp-hptlc). chromatographic retention (rm0) was correlated with...

This review examines the progress that is being made towards the in silico prediction of brain permeation. Following a brief introduction to the blood-brain barrier, the datasets currently available for in silico modeling are discussed. Recent developments in in silico models of brain permeation are summarized in the context of the current state of the art in prediction accuracy. An analysis of...

Background: The clinical phenotyping of patients with achromatopsia harboring variants in phosphordiesterase 6C (PDE6C) has poorly been described in the literature. PDE6C encodes the catalytic subunit of the cone phosphodiesterase, which hydrolyzes the cyclic guanosine monophosphate that proceeds with the hyperpolarization of photoreceptor cell membranes, as the final step of the phototransduct...

The use of methods at molecular scale for the discovery new potential active ligands, as well previously unknown binding sites target proteins, is now an established reality. Literature offers many successful stories compounds developed starting from insights obtained in silico and approved by Food Drug Administration (FDA). One most famous examples raltegravir, a HIV integrase inhibitor, which...