Stone AJ, Copp SW, McCord JL, Kaufman MP. Femoral artery ligation increases the responses of thin-fiber muscle afferents to contraction. J Neurophysiol 113: 3961–3966, 2015. First published April 8, 2015; doi:10.1152/jn.00288.2015.—Previous evidence has shown that ligating the femoral artery for 72 h resulted in an exaggerated exercise pressor reflex. To provide electrophysiological evidence fo...

Cnidii Monnieri [Cnidium monnieri (L.) Cusson] is one of the most common used herbal plants in the treatment of numerous ailments including reproductive diseases for hundred of years. Total coumarins of Cnidii Monnieri (TCCM) is a key ingredient. Osthole (Ost) and Imperatorin (Imp) are two main effective ingredients enriched in TCCM. The purpose of this study was to investigate the pharmacokine...

Steady state kinetics of hypoxanthine guanine phosphoribosyltransferase-catalyzed reactions are studied. The results obtained suggest that IMP, GMP, P-Rib-PP, and pyrophosphate bind to the same enzyme form, while hypoxanthine and guanine bind to a different form. Guanine activates IMP-pyrophosphorolysis. During the reaction guanlne and IMP are consumed with formation of GMP and hypoxanthine (IM...

Intramuscular pressure (IMP) and electromyography (EMG) mirror muscle force in the nonfatigued muscle during static contractions. The present study explores whether the constant IMP-EMG relationship with increased force may be extended to dynamic contractions and to fatigued muscle. IMP and EMG were recorded from shoulder muscles in three sessions: 1). brief static arm abductions at angles from...

Intramuscular pressure (IMP) is the hydrostatic fluid pressure that is directly related to muscle force production. Electromechanical delay (EMD) provides a link between mechanical and electrophysiological quantities and IMP has potential to detect local electromechanical changes. The goal of this study was to assess the relationship of IMP with the mechanical and electrical characteristics of ...

Sexual differentiation in the silkworm Bombyx mori is controlled by sex-specific splicing of Bmdsx, in which exons 3 and 4 are skipped in males. B. mori insulin-like growth factor II mRNA-binding protein (Imp) is a factor involved in the male-specific splicing of Bmdsx. In this study, we found that the male-specific Imp mRNA is formed as a result of the inclusion of exon 8 and the promoter-dist...

BACKGROUND AND STUDY AIMS Current diagnostic testing is inadequate to determine the malignant potential of pancreatic cysts, resulting in overcautious patient management. Integrated molecular pathology (IMP) testing combines molecular analysis with first-line test results (cytology, imaging, and fluid chemistry) to assess the malignant potential of pancreatic cysts. This multicenter study aimed...

The localization of specific mRNAs can establish local protein gradients that generate and control the development of cellular asymmetries. While all evidence underscores the importance of the cytoskeleton in the transport and localization of RNAs, we have limited knowledge of how these events are regulated. Using a visual screen for motile proteins in a collection of GFP protein trap lines, we...

The Interactive Musical Partner (IMP) is software designed for use in duo improvisations, with one human improviser and one instance of IMP, focusing on a freely improvised duo aesthetic. IMP has Musical Personality Settings (MPS) that can be set prior to performance, and these MPS guide the way IMP responds to musical input. The MPS also govern the probability of particular outcomes from IMP’s...