Abstract Dysregulated humoral immune mechanisms result in immunoglobulin production that is pathogenic and contributes to a wide range of autoimmune diseases transplant rejection. Proteases derived from human pathogens can specifically cleave these immunoglobulins (Ig) potentially eliminate circulating, cell-surface immune-complex Ig classes modulate Ig-mediated autoimmunity inflammation, provi...

OBJECTIVE To assess the impact of immunosuppressive therapy with cyclophosphamide (CYC) and rituximab (RTX) on serum immunoglobulin (Ig) concentrations and B lymphocyte counts in patients with ANCA-associated vasculitides (AAVs). METHODS Retrospective analysis of Ig concentrations and peripheral B cell counts in 55 AAV patients. RESULTS CYC treatment resulted in a decrease in Ig levels (med...

The article by Lombardo and colleagues described high throughput sequencing of the immunoglobulin (Ig) heavy and light chain genes from African Burkitt lymphomas (BLs). On the basis of their analysis and, in particular, because of the frequent lack of detection of Ig DHJH or VHDHJH rearrangements on the nonexpressed Ig heavy (IgH) chain allele, as well as ongoing mutation on the nonexpressed al...

The functions of immunoglobulin transporting receptors (Ig transporting receptors) in immune system encompass from passive immunity to adaptive immunity by transporting immunoglobulins (Igs) and prolonging their half-life as well as enhancing immunosurveillance. Prior to the weaning, Ig transportations from mother to offspring confer the immediate passive immunity for neonates. After the weanin...

Immunoglobulin light chain (IgL) rearrangements occur more frequently at Ig kappa than at Ig lambda. Previous results suggested that the unrearranged Ig kappa locus negatively regulates Ig lambda transcription and/or rearrangement. Here, we demonstrate that expression of a VJ lambda 1-joint inserted into its physiological position in the Ig lambda locus is independent of Ig kappa rearrangements...

The lack of effective treatment for CRPC is the leading cause death in prostate cancer patients. However, exhibits high immunoglobulin (Ig) expression. Ig, one most important immune molecules, a unique product B lymphocytes and plays an role defence. expression IgG malignant tumour tissues positively correlated with degree malignancy, promotes proliferation metastasis cells. A retrospective ana...

Progenitor-B cells recombine their immunoglobulin (Ig) loci to create unique antigen receptors. Despite a common recombination machinery, the Ig heavy and Ig light chain loci rearrange in a stepwise manner. We studied pre-pro-B cells and Rag(-/-) progenitor-B cells to determine whether Ig locus contraction or nuclear positioning is decisive for stepwise rearrangements. We found that both Ig loc...

A central problem in cellular immunology is the elucidation of the nature of the antigen receptor molecules on the surface of thymus-dependent lymphocytes (T cells). Antigen receptors on thymus-independent lymphocytes (B cel|s) are readily detectable and have been identified as being mainly monomeric IgM molecules (1-6). However direct attempts to demonstrate immunoglobulin (Ig) molecules on th...

The chicken DT40 B lymphocyte line diversifies its immunoglobulin (Ig) V genes through translesion DNA synthesis-dependent point mutations (Ig hypermutation) and homologous recombination (HR)-dependent Ig gene conversion. The error-prone biochemical characteristic of the A family DNA polymerases Polnu and Pol led us to explore the role of these polymerases in Ig gene diversification in DT40 cel...

Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin (Ig) heavy-chain (hIGH), kappa-chain (hIGK), and lambda-chain (hIGL) germline loci produced physiological levels of hIgGs when both of the bovin...