non-enzymatic glycosylation of proteins is one of the key mechanisms in the pathogenesis of diabetic complications. glycation of igg is of special interest due to its possible influence on the functionality of immunoglobulins and overall immuno-competence. the aim of this study was to clarify more details of in vitro glycation of igg and to study the effect of this modification on its interatio...

although research on adult subjects has demonstrated a positive correlation between humor and increased concentrations of secretory immunoglobulin a, the literature has not addressed whether humor might have a similar effect on children. fifth grade student volunteers (n= 190) at elementary schools in hamadan were randomly assigned to treatment and control groups. the study compared secretory i...

Background: Waldenstrom macroglobulinemia is a lymphoplasmacytic lymphoma with elevated serum immunoglobulin M and multi-organ involvement. Primary systemic amyloidosis usually develops due to immunoglobulin light chains depositions in different organs due to an underlying gammopathy. Case presentation: Our patient was an 86-year-old man with macroglossia, ecchymotic patches and bullous lesion...

Adjuvant high dose IVIgs are being used increasingly in a range of immune-mediated and auto-immune diseases. Although numerous immunomodulatory mechanisms have been suggested, the exact mechanisms of action are poorly understood. The efficacy of IVIg in certain diseases has been proven in clinical trials, in so far as IVIg is approved as the therapy of choice for Kawasaki syndrome and idiopathi...

the main objective of this study was to evaluate the effect of dietary inclusion of wheat or corn as the main source of starch in prepartum diets on colostrum composition, colostrum igg1 and igg2 concentrations, serum igg1 and igg2 concentrations of calves and efficiency of igg1, igg2 and total ig absorption. for this purpose, thirty primiparous and twenty multiparous holstein cows were used in...

forty patients with cataracts, as well as 40 patients with proven ocular toxoplasmosis were enrolled in this prospective clinical study. serum igg and aqueous igg in both groups were measured by enzyme-linked immunosorbent assay (elisa) and the corresponding ratios were calculated. serum igg/aqueous humor igg ratio was less than 100 in the patient group and more than 100 in the control group. o...

background: mucous membrane pemphigoid (mmp) is considered an autoimmune blistering disease that  predominantly affects mucous membranes. various treatments are available for controlling the diseases, but not all of them may respond. objective: in this review, the data on seventy patients with mmp who were under treatment of intravenous immunoglobulin (ivig) are categorized and then analyzed. t...

toxic epidermal necrolysis is a potentially life-threatening disease, which needs necessary treatment. we present a 12 years old female who was a known case of idiopathic generalized tonic-clonic convulsion and presented with fever, diarrhea and generalized erythematous eruption after 2 weeks of being under treatment with maintenance doses of lamotrigine (ltg) and valproate (vpa). the eruption ...

hyper - immunoglobulin e syndrome is a rare primary immunodeficiency disease characterized by recurrent abscess formation, respiratory tract infections and very high titers of serum ige associated with peculiar face and skeletal features. we report a seven-year old  girl  presenting with persistent productive cough and  history of chronic eczematoid facial lesions since infancy  and  two episod...