Melanoma development not only involves genetic and epigenetic changes that take place within the cell, but also involves processes determined collectively by micro-environmental factors, including cell-cell interactions and communications. During the transition from normal cells to benign and malignant lesions, and subsequently to metastatic cancer, stepwise changes in intercellular communicati...

Hormone-sensitive lipase and cholesterol ester hydrolase of chicken adipose tissue were markedly activated by adenosine 3’:5’-monophosphate (CAMP)-dependent protein kinase (on the average, 235 to 275%); occasionally as much as 1000%). Diglyceride and monoglyceride hydrolases were also activated, but to a lesser extent (60 to 87%). The activation of all four hydrolases was inhibited by protein k...

Latar Belakang: Penyakit Corona virus 19 (COVID-19) yang disebabkan oleh SARS-COV-2 terjadi melalui droplet dengan menyerang saluran pernafasan reseptor ACE2, menyebabkan pneumonia berat yaitu Acute Respiratory Distress Syndrome. Pemeriksaan laboratorium penting dalam menunjang diagnosis dan menilai prognosis penyakit COVID-19.Tujuan: Tinjauan ini menjelaskan peran pengembangan COVID-19 pada te...

Protein-Energy Malnutrition (PEM) is believed to lead to an increased susceptibility to infection, or cause impaired immunity. Infection, occurring with malnutrition, is a major cause of morbidity in all age groups and is responsible for two-thirds of all death under 5 yr of age in developing countries. Many cells of the immune system are known to depend for their function on metabolic pathways...

Computational design of novel proteins with well-defined functions is an ongoing topic in computational biology. In this work, we generated and optimized a new synthetic fusion protein using an evolutionary approach. The optimization was guided by directed evolution based on hydrophobicity scores, molecular weight, and secondary structure predictions. Several methods were used to refine the mod...

M icroalbuminuria is generally considered as the best available noninvasive predictor of diabetic nephropathy. However, several studies have shown that increases in certain urinary proteins (immunoglobin G [IgG] [1–3], transferrin [Tf] [4–7], and ceruloplasmin [CRL] [3,8]) were found in normoalbuminuric diabetic patients. Recently, we reported that in normoalbuminuric diabetic patients, there w...